Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly

doi:10.1021/acsnano.9b03444

	Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly
	Ji, Wei 1; Yuan, Chengqian 2; Zilberzwige-Tal, Shai 1; Xin, Ruirui 2; Chakraborty, Priyadarshi 1; Tao, Kai 1; Gilead, Sharon 1; Yan, Xuehai 2; Gazit, Ehud 1,3
刊名	ACS NANO
	2019-06-01
卷号	13 期号:6 页码:7300-7309
关键词	hydrogels self-assembly nanostructures dipeptide supramolecular chemistry
ISSN号	1936-0851
DOI	10.1021/acsnano.9b03444
英文摘要	The misfolding of proteins and peptides potentially leads to a conformation transition from an alpha-helix or random coil to beta-sheet-rich fibril structures, which are associated with various amyloid degenerative disorders. Inhibition of the beta-sheet aggregate formation and control of the structural transition could therefore attenuate the development of amyloid-associated diseases. However, the structural transitions of proteins and peptides are extraordinarily complex processes that are still not fully understood and thus challenging to manipulate. To simplify this complexity, herein, the effect of metal ions on the inhibition of amyloid-like beta-sheet dipeptide self assembly is investigated. By changing the type and ratio of the metal ion/dipeptide mixture, structural transformation is achieved from a beta-sheet to a superhelix or random coil, as confirmed by experimental results and computational studies. Furthermore, the obtained supramolecular metallogel exhibits excellent in vitro DNA binding and diffusion capability due to the positive charge of the metal/dipeptide complex. This work may facilitate the understanding of the role of metal ions in inhibiting amyloid formation and broaden the future applications of supramolecular metallogels in three-dimensional (3D) DNA biochip, cell culture, and drug delivery.
资助项目	European Research Council under the European Union[694426] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS关键词	FIBRILS ; DIPHENYLALANINE ; TRANSITION ; HYDROGELS ; POLYMORPHISM ; ETIOLOGY ; BINDING
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000473248300116
资助机构	European Research Council under the European Union ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/30261]
专题	中国科学院过程工程研究所
通讯作者	Yan, Xuehai; Gazit, Ehud
作者单位	1.Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-6997801 Tel Aviv, Israel 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Tel Aviv Univ, Iby & Aladar Fleischman Fac Engn, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, Israel
推荐引用方式 GB/T 7714	Ji, Wei,Yuan, Chengqian,Zilberzwige-Tal, Shai,et al. Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly[J]. ACS NANO,2019,13(6):7300-7309.
APA	Ji, Wei.,Yuan, Chengqian.,Zilberzwige-Tal, Shai.,Xin, Ruirui.,Chakraborty, Priyadarshi.,...&Gazit, Ehud.(2019).Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly.ACS NANO,13(6),7300-7309.
MLA	Ji, Wei,et al."Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly".ACS NANO 13.6(2019):7300-7309.