Transport of a graphene nanosheet sandwiched inside cell membranes

doi:10.1126/sciadv.aaw3192

	Transport of a graphene nanosheet sandwiched inside cell membranes
	Chen, Pengyu 1; Yue, Hua 2; Zhai, Xiaobo 3; Huang, Zihan 1; Ma, Guang-Hui 2,4; Wei, Wei 2,4; Yan, Li-Tang 1
刊名	SCIENCE ADVANCES
	2019-06-01
卷号	5 期号:6 页码:13
ISSN号	2375-2548
DOI	10.1126/sciadv.aaw3192
英文摘要	The transport of nanoparticles at bio-nano interfaces is essential for many cellular responses and biomedical applications. How two-dimensional nanomaterials, such as graphene and transition-metal dichalcogenides, diffuse along the cell membrane is, however, unknown, posing an urgent and important issue to promote their applications in the biomedical area. Here, we show that the transport of graphene oxides (GOs) sandwiched inside cell membranes varies from Brownian to Levy and even directional dynamics. Specifically, experiments evidence sandwiched graphene-cell membrane superstructures in different cells. Combined simulations and analysis identify a sandwiched GO-induced pore in cellmembrane leaflets, spanning unstable, metastable, and stable states. An analyticalmodel that rationalizes the regimes of thesemembrane-pore states fits simulations quantitatively, resulting in amechanistic interpretation of the emergence of Levy and directional dynamics. We finally demonstrate the applicability of sandwiched GOs in enhanced efficiency of membrane-specific drug delivery. Our findings inform approaches to programming intramembrane transport of two-dimensional nanomaterials toward advantageous biomedical applications.
资助项目	National Natural Science Foundation of China[21873053] ; National Natural Science Foundation of China[51633003] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[11504290] ; National Key R&D Program of China[2016YFA0202500] ; National Key R&D Program of China[2017YFA0207900]
WOS关键词	DISSIPATIVE PARTICLE DYNAMICS ; COMPUTER-SIMULATION ; DRUG-DELIVERY ; NANOPARTICLES ; NANOMATERIALS ; DIRECTIONALITY ; VESICULATION ; ENDOCYTOSIS ; CURVATURE ; DIFFUSION
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000473798500072
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/30132]
专题	中国科学院过程工程研究所
通讯作者	Wei, Wei; Yan, Li-Tang
作者单位	1.Tsinghua Univ, Dept Chem Engn, State Key Lab Chem Engn, Beijing 100084, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Xian Univ Sci & Technol, Coll Sci, Xian 710054, Shaanxi, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Pengyu,Yue, Hua,Zhai, Xiaobo,et al. Transport of a graphene nanosheet sandwiched inside cell membranes[J]. SCIENCE ADVANCES,2019,5(6):13.
APA	Chen, Pengyu.,Yue, Hua.,Zhai, Xiaobo.,Huang, Zihan.,Ma, Guang-Hui.,...&Yan, Li-Tang.(2019).Transport of a graphene nanosheet sandwiched inside cell membranes.SCIENCE ADVANCES,5(6),13.
MLA	Chen, Pengyu,et al."Transport of a graphene nanosheet sandwiched inside cell membranes".SCIENCE ADVANCES 5.6(2019):13.