Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer

doi:10.1021/acsnano.9b00892

	Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer
	Zhang, Fan 1; Li, Feng 1; Lu, Gui-Hong 1; Nie, Weidong 1; Zhang, Lijun 2,3; Lv, Yanlin 2; Bao, Weier 2,3; Gao, Xiaoyong 2; Wei, Wei 2,3; Pu, Kanyi 4
刊名	ACS NANO
	2019-05-01
卷号	13 期号:5 页码:5662-5673
关键词	biomimetic magnetosomes PD-1 antibody TGF-beta inhibitor immunomodulation ferroptosis cancer therapy
ISSN号	1936-0851
DOI	10.1021/acsnano.9b00892
英文摘要	As traditional anticancer treatments fail to significantly improve the prognoses, exploration of therapeutic modalities is urgently needed. Herein, a biomimetic magnetosome is constructed to favor the ferroptosis/immunomodulation synergism in cancer. This magnetosome is composed of an Fe304 magnetic nanocluster (NC) as the core and pre-engineered leukocyte membranes as the cloak, wherein TGF-fl inhibitor (Ti) can be loaded inside the membrane and PD-1 antibody (Pa) can be anchored on the membrane surface. After intravenous injection, the membrane camouflage results in long circulation, and the NC core with magnetization and superparamagnetism enables magnetic targeting with magnetic resonance imaging (MRI) guidance. Once inside the tumor, Pa and Ti cooperate to create an immunogenic microenvironment, which increases the amount of H202 in polarized MI macrophages and thus promotes reaction with Fe ions released from NCs. The generated hydroxyl radicals (*OH) subsequently induce lethal ferroptosis to tumor cells, and the exposed tumor antigen, in turn, improves the microenvironment immunogenicity. The synergism of immunomodulation and ferroptosis in such a cyclical manner therefore leads to potent therapeutic effects with few abnormalities, which supports the engineered magnetosomes as a promising combination modality for anticancer therapy.
资助项目	National Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Key R&D Program of China[2017YFA0207900]
WOS关键词	CELL-DEATH ; TUMOR ; NANOPARTICLES ; THERAPY ; CHEMOTHERAPY ; FERROPTOSIS ; GENERATION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000469886300073
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/29889]
专题	中国科学院过程工程研究所
通讯作者	Wei, Wei; Xie, Hai-Yan
作者单位	1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637457, Singapore
推荐引用方式 GB/T 7714	Zhang, Fan,Li, Feng,Lu, Gui-Hong,et al. Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer[J]. ACS NANO,2019,13(5):5662-5673.
APA	Zhang, Fan.,Li, Feng.,Lu, Gui-Hong.,Nie, Weidong.,Zhang, Lijun.,...&Xie, Hai-Yan.(2019).Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer.ACS NANO,13(5),5662-5673.
MLA	Zhang, Fan,et al."Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer".ACS NANO 13.5(2019):5662-5673.