Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy

doi:10.1016/j.jcis.2019.04.051

	Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy
	Zhao, Jie 1; Wang, Anhe 2; Si, Tieyan 3; Hong, Jong-Dal 4; Li, Junbai 1,5
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2019-08-01
卷号	549 页码:9-15
关键词	Gold nanorods Multicompartment mesoporous silica nanoparticles Ultra-stable Photostability Photothermal therapy
ISSN号	0021-9797
DOI	10.1016/j.jcis.2019.04.051
英文摘要	Photothermal therapy (PTT) based on photothermal effect of the gold nanostructures, has been widely applied as a noninvasive therapy approach in cancer treatment. However, bare Au nanoparticles are not stable enough during the irradiation process, and cannot harvest sufficient energy to kill tumor cells. To improve this, we have fabricated a stable bioagent by loading gold nanorods (AuNRs) into multicompartment mesoporous silica nanoparticles (MMSNs) for the photothermal therapy. The procedure is that when AuNRs entrapped in MMSNs are irradiated by a laser in the near-infrared region of 808 nm, the hyperthermia produced by the assembled composites is strong enough to damage tumor tissues directly. Both experiments in vitro and in vivo demonstrate that the nanocomposites are perfect candidates as PTT agents for the cancer treatment with a high efficiency. Furthermore, it is found that the nanocomposites have good photostability and consistent temperature fluctuation over 11 on/off cycles with irradiation which the pure AuNRs will not have. (C) 2019 Elsevier Inc. All rights reserved.
资助项目	Research Grant of Incheon National University in 2018 ; National Nature Science Foundation of China[21433010]
WOS关键词	POLYMER NANOPARTICLES ; DRUG-DELIVERY ; NANOCAGES ; GRAPHENE ; ABLATION ; CARRIER ; SHAPE
WOS研究方向	Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000469902100002
资助机构	Research Grant of Incheon National University in 2018 ; National Nature Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/29826]
专题	中国科学院过程工程研究所
通讯作者	Hong, Jong-Dal; Li, Junbai
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, BNLMS, Bei Yi Jie 2, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Harbin Inst Technol, Micro Nanotechnol Res Ctr, Key Lab Microsyst & Microstruct Mfg, Harbin, Heilongjiang, Peoples R China 4.Incheon Natl Univ, Dept Chem, 119 Acad Ro, Incheon 21022, South Korea 5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jie,Wang, Anhe,Si, Tieyan,et al. Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,549:9-15.
APA	Zhao, Jie,Wang, Anhe,Si, Tieyan,Hong, Jong-Dal,&Li, Junbai.(2019).Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,549,9-15.
MLA	Zhao, Jie,et al."Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 549(2019):9-15.