Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17

doi:10.1002/hlca.201500218

	Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17
	Bechthold, Andreas 1; Zhu, Jing 1; Liu, Tao 2; Zhang, Songya 1; Samra, Suzan 1; Pan, Huaqi 3; Bai, Jiao 4; Hua, Huiming 4
刊名	HELVETICA CHIMICA ACTA
	2016-03-01
卷号	99 期号:3 页码:215-219
关键词	Secondary Metabolites Fungi Myrothecium Glycosylated Polyketides Antibacterial Activity
ISSN号	0018-019X
DOI	10.1002/hlca.201500218
英文摘要	Based on the chemical analysis and targeted bioactivity screening, a new polyketide glycoside, myrothecoside, was isolated from a terrestrial halotolerant fungus, Myrothecium sp. GS-17. The structure of myrothecoside was elucidated on the basis of extensive spectroscopic analysis including 1D- and 2D-NMR (H-1,H-1-COSY, HSQC, HMBC, and NOESY) experiments, combined with mass spectroscopic data and physicochemical properties. This compound exhibited weak cytotoxicity against human leukemia (HL-60) cancer cell with an IG(50) value of 63.61m, and also antifungal activities against plant pathogenic fungi Rhizoctonia solani and Fusarium oxysporum using standard agar diffusion tests at 20 mu g/disk.
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000373611500008
内容类型	期刊论文
源URL	[http://210.72.129.5/handle/321005/122592]
专题	中国科学院沈阳应用生态研究所
通讯作者	Bechthold, Andreas
作者单位	1.Univ Freiburg, Inst Pharmazeut Biol & Biotechnol, D-79104 Freiburg, Germany 2.China Med Univ, Sch Pharm, Dept Nat Prod Chem, Shenyang 110001, Peoples R China 3.Chinese Acad Sci, Inst Appl Ecol, Shenyang 110016, Peoples R China 4.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Bechthold, Andreas,Zhu, Jing,Liu, Tao,et al. Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17[J]. HELVETICA CHIMICA ACTA,2016,99(3):215-219.
APA	Bechthold, Andreas.,Zhu, Jing.,Liu, Tao.,Zhang, Songya.,Samra, Suzan.,...&Hua, Huiming.(2016).Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17.HELVETICA CHIMICA ACTA,99(3),215-219.
MLA	Bechthold, Andreas,et al."Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17".HELVETICA CHIMICA ACTA 99.3(2016):215-219.