Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice

doi:10.1080/13880209.2018.1563621

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice
	Yang, Haoyue1,2,3 ; Xing, Ronge1,2,3 ; Liu, Song 1,2,3; Yu, Huahua1,2,3 ; Li, Pengcheng1,2,3
刊名	PHARMACEUTICAL BIOLOGY
	2019-01-24
卷号	57 期号:1 页码:29-37
关键词	GABA thyroid hormone synthesis myocardial preservation anti-hypothyroidism
ISSN号	1388-0209
DOI	10.1080/13880209.2018.1563621
通讯作者	Xing, Ronge(xingronge@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要	Context: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, gamma-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. Objective: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. Materials and methods: Adult male Kumning mice (N = 90) were exposed to NaF (50 mg/kg) for 30 days as a model of hypothyroidism. To evaluate the effects of GABA administration, fluoride-exposed mice received either thyroid tablets, or low (25 mg/kg), medium (50 mg/kg) or high (75 mg/kg) concentrations of pure GABA orally for 14 days groups (N = 10 each). The effects of low (50 mg/kg); medium (75 mg/kg) and high (100 mg/kg) concentrations of laboratory-separated GABA were assessed for comparison. Effects on thyroid hormone production, oxidative stress, thyroid function-associated genes, and side-effects during therapy were measured. Results: GABA supplementation in fluoride-exposed mice significantly increased the expression of thyroid TG, TPO, and NIS (P < 0.05), significantly improved the thyroid redox state (P < 0.05), modulated the expression of thyroid function-associated genes, conferred liver metabolic protection, and prevented changes to myocardial morphology, thus reducing side effects. Both pure and laboratory-separated GABA displayed comparative protective effects. Discussion and conclusion: Our findings support the assertion that GABA exerts therapeutic potential in hypothyroidism. The design and use of human GABA trials to improve therapeutic outcomes in hypothyroidism are now warranted.
资助项目	Key Research Program of the Chinese Academy of Sciences[KFZD-SW-106] ; Commonwealth of State Oceanic Administration People's Republic of China[201405038-2] ; Innovation and Development of Marine Economy Demonstration City Project ; Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02]
WOS研究方向	Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000457344700001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/160608]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Xing, Ronge; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Yang, Haoyue,Xing, Ronge,Liu, Song,et al. Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice[J]. PHARMACEUTICAL BIOLOGY,2019,57(1):29-37.
APA	Yang, Haoyue,Xing, Ronge,Liu, Song,Yu, Huahua,&Li, Pengcheng.(2019).Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.PHARMACEUTICAL BIOLOGY,57(1),29-37.
MLA	Yang, Haoyue,et al."Analysis of the protective effects of gamma-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice".PHARMACEUTICAL BIOLOGY 57.1(2019):29-37.