Synthesis, characterization, and antifungal evaluation of diethoxyphosphoryl polyaminoethyl chitosan derivatives

doi:10.1016/j.carbpol.2018.02.056

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Synthesis, characterization, and antifungal evaluation of diethoxyphosphoryl polyaminoethyl chitosan derivatives
	Fan, Zhaoqian 1,2,3; Qin, Yukun 1,2; Liu, Song 1,2; Xing, Ronge1,2 ; Yu, Huahua1,2 ; Chen, Xiaolin 1,2; Li, Kecheng 1,2; Li, Pengcheng1,2
刊名	CARBOHYDRATE POLYMERS
	2018-06-15
卷号	190 页码:1-11
关键词	Chitosan Polyaminoethyl Phosphoryl Antifungal
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2018.02.056
通讯作者	Qin, Yukun(ykqin@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要	Botrytis cinerea, Phytophthora capsici Leonian, and Fusarium solani are important plant pathogenic fungi which can cause great crop losses worldwide, but their control methods are limited. It is necessary to develop efficient and green fungicides from abundant marine resources. Chitosan is a non-toxic, biodegradable, biocompatible marine polysaccharide which has prospective applications in agriculture. In this paper, to increase the antifungal activity of chitosan for application, novel water-soluble functional chitosan derivatives were synthesized by grafting polyaminoethyl and diethoxyphosphoryl groups in accordance with a strategy of improving protonation potential. The derivatives were characterized by FTIR, NMR, XRD, SEM, Gaussian 09 and elemental analysis. The antifungal activities against the three fungi and the cytotoxicity were estimated in vitro. The results showed that the derivatives had better antifungal activities and water solubility than chitosan, and had good biocompatibility. They confirmed that these chitosan derivatives can be developed as antifungal agents for plant protection purposes.
资助项目	National Natural Science Foundation of China[41306071] ; Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Public Science and Technology Research Funds Projects of Ocean[201305016-2] ; Public Science and Technology Research Funds Projects of Ocean[201405038-2] ; CAS STS Program[KFJ-SW-STS-143]
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000429425500001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/158746]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Qin, Yukun; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Fan, Zhaoqian,Qin, Yukun,Liu, Song,et al. Synthesis, characterization, and antifungal evaluation of diethoxyphosphoryl polyaminoethyl chitosan derivatives[J]. CARBOHYDRATE POLYMERS,2018,190:1-11.
APA	Fan, Zhaoqian.,Qin, Yukun.,Liu, Song.,Xing, Ronge.,Yu, Huahua.,...&Li, Pengcheng.(2018).Synthesis, characterization, and antifungal evaluation of diethoxyphosphoryl polyaminoethyl chitosan derivatives.CARBOHYDRATE POLYMERS,190,1-11.
MLA	Fan, Zhaoqian,et al."Synthesis, characterization, and antifungal evaluation of diethoxyphosphoryl polyaminoethyl chitosan derivatives".CARBOHYDRATE POLYMERS 190(2018):1-11.