Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment

doi:10.7150/thno.20548

	Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment
	Yong, Y; Yang, G; Dai, YH; Song, X; Pan, Y; Ge, CC; Yong Y(雍媛); Cheng, XJ
刊名	THERANOSTICS
	2017
卷号	7 期号:17 页码:4087-4098
关键词	multimodal imaging radiation therapy hypoxia DNA repair synergistic therapy
ISSN号	1838-7640
DOI	10.7150/thno.20548
文献子类	Article
英文摘要	Nanotechniques that can improve the effectiveness of radiotherapy (RT) by integrating it with multimodal imaging are highly desirable. Results In this study, we fabricated Bi2S3 nanorods that have attractive features such as their ability to function as contrast agents for X-ray computed tomography (CT) and photoacoustic (PA) imaging as well as good biocompatibility. Both in vitro and in vivo studies confirmed that the Bi2S3 nanoagents could potentiate the lethal effects of radiation via amplifying the local radiation dose and enhancing the anti-tumor efficacy of RT by augmenting the photo-thermal effect. Furthermore, the nanoagent-mediated hyperthermia could effectively increase the oxygen concentration in hypoxic regions thereby inhibiting the expression of hypoxia-inducible factor (HIF-1 alpha). This, in turn, interfered with DNA repair via decreasing the expression of DNA repair-related proteins to overcome radio-resistance. Also, RT combined with nanoagent-mediated hyperthermia could substantially suppress tumor metastasis via down-regulating angiogenic factors. Conclusion In summary, we constructed a single-component powerful nanoagent for CT/PA imaging-guided tumor radiotherapy and, most importantly, explored the potential mechanisms of nanoagent-mediated photo-thermal treatment for enhancing the efficacy of RT in a synergistic manner.
WOS关键词	DOUBLE-STRAND BREAKS ; IONIZING-RADIATION ; SYNERGISTIC THERAPY ; POLY(ADP-RIBOSE) POLYMERASE-1 ; MILD HYPERTHERMIA ; TUMOR OXYGENATION ; DNA-DAMAGE ; CANCER ; NANOPARTICLES ; REPAIR
WOS研究方向	Research & Experimental Medicine
语种	英语
WOS记录号	WOS:000412296800002
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285285]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Yong, Y,Yang, G,Dai, YH,et al. Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment[J]. THERANOSTICS,2017,7(17):4087-4098.
APA	Yong, Y.,Yang, G.,Dai, YH.,Song, X.,Pan, Y.,...&Cheng, XJ.(2017).Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment.THERANOSTICS,7(17),4087-4098.
MLA	Yong, Y,et al."Enhanced Radiotherapy using Bismuth Sulfide Nanoagents Combined with Photo-thermal Treatment".THERANOSTICS 7.17(2017):4087-4098.