Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation

doi:10.1039/c7nr04365a

	Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation
	Geng H(耿会); Chang YN(常亚男); Bai X(白雪); Yuan Q(袁卿); Gu WH(古伟宏); Li J(李娟); Chen K(陈奎); Xing GM(邢更妹); Geng, H; Chang, YN
刊名	NANOSCALE
	2017
卷号	9 期号:34 页码:12516-12523
ISSN号	2040-3364
DOI	10.1039/c7nr04365a
文献子类	Article
英文摘要	Bone health requires regulation of homeostatic equilibrium between osteoblasts and osteoclasts. The over-activation of osteoclasts can disrupt bone metabolism, resulting in osteoporosis and other boneloss diseases. Fullerenol, a polyhydroxy derivative of fullerene, exhibits excellent biocompatibility. Here we show that fullerenol nanoparticles exert two functions: inhibition of osteoclastic differentiation and blockage of pre-osteoclast fusion to restructure osteoclast maturation and function. Experimentally, the nanoparticles reduced pre-osteoclast migration and inhibited ruffled border formation to block their maturation. In addition, fullerenol dose-dependently restricted the differentiation of bone marrow macrophage cells (BMMs) to form osteoclasts following treatment with macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor (NF)-kappa B (RANKL) to activate NF-kappa B and mitogen activating protein kinase (MAPK) signaling pathways. It is possible that the very small size of fullerenol allows it to directly cross the cellular membrane to access the cytoplasm and regulate osteoclastogenesis from BMMs. Our results suggest that fullerenol could be used to treat bone-loss diseases such as osteoporosis.
电子版国际标准刊号	2040-3372
WOS关键词	ACTIN ; BONE ; MECHANISMS ; FUSION ; ORGANIZATION ; ACTIVATION ; PRECURSORS ; MIGRATION ; PODOSOME ; DISEASE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000409215300035
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285266]
专题	高能物理研究所_多学科研究中心高能物理研究所_粒子天体物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Geng H,Chang YN,Bai X,et al. Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation[J]. NANOSCALE,2017,9(34):12516-12523.
APA	耿会.,常亚男.,白雪.,袁卿.,古伟宏.,...&Xing, GM.(2017).Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation.NANOSCALE,9(34),12516-12523.
MLA	耿会,et al."Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation".NANOSCALE 9.34(2017):12516-12523.