Bioaccumulation and Toxicity of C-13-Skeleton Labeled Graphene Oxide in Wheat

doi:10.1021/acs.est.7b00822

	Bioaccumulation and Toxicity of C-13-Skeleton Labeled Graphene Oxide in Wheat
	Yang, ST; Chen, LY; Chang, XL; Qu, XL; Li, HL; Wang, CL; Chang XL(常雪灵); Li HL(李红亮); Wang CL(王成龙)
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2017
卷号	51 期号:17 页码:10146-10153
ISSN号	0013-936X
DOI	10.1021/acs.est.7b00822
文献子类	Article
英文摘要	Graphene nanomaterials have many diverse applications, but are considered to be emerging environmental pollutants. Thus, their potential environmental risks and biosafety are receiving increased attention. Bioaccumulation and toxicity evaluations in plants are essential for biosafety assessment. In this study, C-13-stable isotope labeling of the carbon skeleton of graphene oxide (GO) was applied to investigate the bioaccumulation and toxicity of GO in wheat. Bioaccumulation of GO was accurately quantified according to the C-13/C-12 ratio. Wheat seedlings were exposed to C-13-labeled GO at 1.0 mg/mL in nutrient solution for 15 d. C-13-GO accumulated predominantly in the root with a content of 112 mu g/g at day 15, hindered the development and growth of wheat plants, disrupted root structure and cellular ultrastructure, and promoted oxidative stress. The GO that accumulated in the root showed extremely limited translocation to the stem and leaves. During the experimental period, GO was excreted slowly from the root. GO inhibited the germination of wheat seeds at high concentrations (>= 0.4 mg/mL). The mechanism of GO toxicity to wheat may be associated with oxidative stress induced by GO bioaccumulation, reflected by the changes of malondialdehyde concentration, catalase activity, and peroxidase activity. The results demonstrate that 13C labeling is a promising method to investigate environmental impacts and fates of carbon nanomaterials in biological systems.
电子版国际标准刊号	1520-5851
WOS关键词	CARBON NANOTUBES ; HYDROTHERMAL PREPARATION ; ARABIDOPSIS-THALIANA ; OXIDATIVE STRESS ; IN-VIVO ; NANOPARTICLES ; GROWTH ; L. ; NANOMATERIALS ; CYTOTOXICITY
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
WOS记录号	WOS:000410255800078
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285147]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Yang, ST,Chen, LY,Chang, XL,et al. Bioaccumulation and Toxicity of C-13-Skeleton Labeled Graphene Oxide in Wheat[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2017,51(17):10146-10153.
APA	Yang, ST.,Chen, LY.,Chang, XL.,Qu, XL.,Li, HL.,...&王成龙.(2017).Bioaccumulation and Toxicity of C-13-Skeleton Labeled Graphene Oxide in Wheat.ENVIRONMENTAL SCIENCE & TECHNOLOGY,51(17),10146-10153.
MLA	Yang, ST,et al."Bioaccumulation and Toxicity of C-13-Skeleton Labeled Graphene Oxide in Wheat".ENVIRONMENTAL SCIENCE & TECHNOLOGY 51.17(2017):10146-10153.