Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYFW4: Yb, Er upconversion nanoparticles in mice via different administration routes

doi:10.1039/c7nr00078b

	Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYFW4: Yb, Er upconversion nanoparticles in mice via different administration routes
	Peng, T; Yu J(余杰); Yin WY(尹文艳); Peng T(彭涛); Chang YN(常亚男); Zu Y(祖艳); Li J(李娟); He X(何潇); Gu ZJ(谷战军); Zhao YL(赵宇亮)
刊名	NANOSCALE
	2017
卷号	9 期号:13 页码:4497-4507
ISSN号	2040-3364
DOI	10.1039/c7nr00078b
文献子类	Article
英文摘要	Upconversion nanoparticles (UCNPs) have drawn much attention in biomedicine, and the clinical translation of UCNPs is closely related to their toxicity and metabolism in vivo. In this study, we chose polyethyleneimine modified NaYF4: Yb, Er upconversion nanoparticles (abbreviated as PEI@UCNPs) to systematically study the biodistribution in mice using intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i. g.) administration. The i.p. injected PEI@UCNPs exhibited obvious accumulation in the spleen within 30 days. Comparably, PEI@UCNPs via i. g. administration exhibited an accumulation that decreased with time in various body tissues and were found mainly in the ileum and cecum but were rather low in concentration in the other examined organs. For the i.v. injected group, the UCNPs exhibited an obvious clearance from the body within 30 days and the accumulation in the spleen gradually decreased. Furthermore, Cu-64 labeled PEI@UCNPs were i.v. injected for real-time photon emission computed tomography (PET) imaging to further confirm the biodistribution in mice. Afterward, the excretion routes of the PEI@UCNPs were evaluated. For i.p. injected groups, the UCNPs were slowly and partly excreted via feces and urine for 30 days, and a large number of the UCNPs were steadily excreted via feces for the i.v. group, suggesting that the UCNPs via i.v. injection can be potentially used for imaging and therapy studies in vivo. However, for the i. g. administrated group, most of the UCNPs were excreted through feces within 48 h. Hematology, body weight, and biochemical analysis were used to further quantify the potential toxicity of the UCNPs, and results indicated that there was no over toxicity of the UCNPs in mice at the tested period. This work suggests that the clearance and excretion capabilities of PEI@UCNPs are particularly dependent on their administration routes.
电子版国际标准刊号	2040-3372
WOS关键词	POSITRON-EMISSION-TOMOGRAPHY ; IN-VIVO BIODISTRIBUTION ; DRUG-DELIVERY ; CANCER ; THERAPY ; NANOPHOSPHORS ; NANOCRYSTALS ; NANOPROBES ; TOXICOLOGY ; NANORODS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000397968400016
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285134]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Peng, T,Yu J,Yin WY,et al. Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYFW4: Yb, Er upconversion nanoparticles in mice via different administration routes[J]. NANOSCALE,2017,9(13):4497-4507.
APA	Peng, T.,余杰.,尹文艳.,彭涛.,常亚男.,...&Zhao, YL.(2017).Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYFW4: Yb, Er upconversion nanoparticles in mice via different administration routes.NANOSCALE,9(13),4497-4507.
MLA	Peng, T,et al."Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYFW4: Yb, Er upconversion nanoparticles in mice via different administration routes".NANOSCALE 9.13(2017):4497-4507.