Multifunctional thermoresponsive designer peptide hydrogels

doi:10.1016/j.actbio.2016.10.014

	Multifunctional thermoresponsive designer peptide hydrogels
	Hemar, Y; De Leon-Rodriguez, LM; Mo, G; Mitra, AK; Cornish, J; Brimble, MA; Mo G(默广)
刊名	ACTA BIOMATERIALIA
	2017
卷号	47 页码:40-49
关键词	Peptide Hydrogel Thermoresponsive Adhesion Enzymatic-cleavage Mechanical characterization
ISSN号	1742-7061
DOI	10.1016/j.actbio.2016.10.014
文献子类	Article
英文摘要	We report the synthesis and characterization of multifunctional peptides comprised of a hydrogel forming beta-sheet peptide segment and a matrix metalloproteinase 2 substrate containing a propargylglycinyl linker that is further derivatized with an RGD peptide sequence via "click" chemistry. In contrast to currently known systems, these multifunctional peptides formed gels that are stiffer than those formed by their respective precursors. All the peptides showed reversible thermoresponsive properties, which render them as suitable lead systems for a variety of possible biomedical applications. Statement of Significance In general, it has been frequently observed that chemical biofunctionalization of peptide hydrogels adversely affects peptide assembly, hydrogel formation or mechanical properties, which severely compromises their application. A functionalization protocol that allows to generate peptide hydrogels that display significantly improved mechanical properties over their unfunctionalized counterparts is reported in this work. These peptides also showed thermoresponsive viscoelastic characteristics, including an example of a peptide hydrogel that displays lower critical solution temperature behaviour. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
电子版国际标准刊号	1878-7568
WOS关键词	SELF-ASSEMBLING BIOMATERIALS ; MESENCHYMAL STEM-CELLS ; BETA-SHEET PEPTIDES ; RATIONAL DESIGN ; POLYPEPTIDE ; MATRICES ; SCAFFOLDS ; THERMOGEL ; SYSTEMS
WOS研究方向	Engineering ; Materials Science
语种	英语
WOS记录号	WOS:000389102600004
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285116]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Hemar, Y,De Leon-Rodriguez, LM,Mo, G,et al. Multifunctional thermoresponsive designer peptide hydrogels[J]. ACTA BIOMATERIALIA,2017,47:40-49.
APA	Hemar, Y.,De Leon-Rodriguez, LM.,Mo, G.,Mitra, AK.,Cornish, J.,...&默广.(2017).Multifunctional thermoresponsive designer peptide hydrogels.ACTA BIOMATERIALIA,47,40-49.
MLA	Hemar, Y,et al."Multifunctional thermoresponsive designer peptide hydrogels".ACTA BIOMATERIALIA 47(2017):40-49.