Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials

doi:10.1002/smll.201602855

	Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials
	Yin, JJ; Jiang XM(江秀梅); Wang LM(王黎明); Tang JL(唐敬龙); Cao MJ(曹明晶); Chen CY(陈春英); Jiang, XM; Wang, LM; Ji, YL; Tang, JL
刊名	SMALL
	2017
卷号	13 期号:10 页码:1602855
ISSN号	1613-6810
DOI	10.1002/smll.201602855
文献子类	Article
英文摘要	As a widely used nanomaterial in daily life, silver nanomaterials may cause great concern to female reproductive system as they are found to penetrate the bloodplacental barrier and gain access to the ovary. However, it is largely unknown about how silver nanomaterials influence ovarian physiology and functions such as hormone production. This study performs in vitro toxicology study of silver nanomaterials, focusing especially on cytotoxicity and steroidogenesis and explores their underlying mechanisms. This study exposes primary rat granulosa cells to gold nanorod core/silver shell nanostructures (Au@Ag NRs), and compares outcomes with cells exposed to gold nanorods. The Au@Ag NRs generate more reactive oxygen species and reduce mitochondrial membrane potential and less production of adenosine triphosphate. Au@Ag NRs promote steroidogenesis, including progesterone and estradiol, in a time-and dose-dependent manner. Chemical reactivity and transformation of Au@Ag NRs are then studied by electron spin resonance spectroscopy and X-ray absorption near edge structure, which analyze the generation of free radical and intracellular silver species. Results suggest that both particle-specific activity and intracellular silver ion release of Au@Ag NR contribute to the toxic response of granulosa cells.
电子版国际标准刊号	1613-6829
WOS关键词	FOLLICLE-STIMULATING-HORMONE ; OXIDATIVE STRESS ; IN-VITRO ; GRANULOSA-CELLS ; CELLULAR UPTAKE ; ALLOY NANOPARTICLES ; EMBRYO DEVELOPMENT ; APOPTOSIS ; CYTOTOXICITY ; MECHANISM
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000397616200014
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/284958]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Yin, JJ,Jiang XM,Wang LM,et al. Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials[J]. SMALL,2017,13(10):1602855.
APA	Yin, JJ.,江秀梅.,王黎明.,唐敬龙.,曹明晶.,...&Chen, CY.(2017).Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials.SMALL,13(10),1602855.
MLA	Yin, JJ,et al."Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials".SMALL 13.10(2017):1602855.