Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging

doi:10.1021/acs.nanolett.8b04252

	Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging
	Zhou, Xin 3; Liu, Maili 3; Zhang, Aidong 1; Hwang, Dennis W.2; Xie, Junshuai 3; Zhang, Zhiying 3; Yuan, Yaping 3; Li, Haidong 3; Chen, Shizhen 3; Yang, Yuqi 3
刊名	NANO LETTERS
	2019
卷号	19 期号:1 页码:441-448
关键词	Magnetic resonance imaging graphene quantum dots contrast agents enhanced relaxivity
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.8b04252
英文摘要	Nano contrast agents (Nano CA) are nanomaterials used to increase contrast in the medical magnetic resonance imaging (MRI). However, the related relaxation mechanism of the Nano CA is not clear yet and little significant breakthrough in relaxivity enhancement has been achieved. Herein, a new hydrophilic Gd-DOTA complex functionalized with different chain length of PEG was synthesized and incorporated into graphene quantum dots (GQD) to obtain paramagnetic graphene quantum dots (PGQD). We performed a variable temperature and variable-field intensity NMR study in aqueous solution on the water exchange and rotational dynamics of three different chain lengths of PGQD. The optimal GQD with paramagnetic chain length shows a great improvement in performance on H-1 NMR relaxometric studies. In vitro results demonstrated that the relaxivity of the designed PGQD could be controlled by regulating the PEG length, and its relaxivity was similar to 16 times higher than that of current commercial MRI contrast agents (e.g., Gd-DTPA), on a "per Gd" basis. The relaxivity of the Nano CA can be rationally tuned to obtain unmatched potentials in MR imaging, exemplified by preparation of the paramagnetic GQD with the enhanced T-1 relaxivity. The fabricated PGQDs with suitable PEG length got the best relaxivity at 1.5 T. After intravenous injection, its feeding process by solid tumor could even be monitored by clinically used 1.5 T MRI scanners. This research will also provide an excellent platform for the design and synthesis of highly effective MR contrast agents.
资助项目	National Natural Science Foundation of China[81625011] ; National Natural Science Foundation of China[21575157] ; National Natural Science Foundation of China[21605158] ; National Natural Science Foundation of China[81227902] ; National Key R&D Program of China[2017YFA0505400] ; National Key R&D Program of China[2016YFC1304704] ; K.C Wong Education Foundation ; CAS[QYZDY-SSW-SLH018] ; Hubei Provincial Natural Science Foundation of China[2016CFB184] ; Hubei Provincial Natural Science Foundation of China[2017CFA013]
WOS关键词	MAGNETIC-RESONANCE ; CONTRAST AGENTS ; NANOPARTICLES ; NANOMATERIALS ; DELIVERY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000455561300056
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; K.C Wong Education Foundation ; K.C Wong Education Foundation ; CAS ; CAS ; Hubei Provincial Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; K.C Wong Education Foundation ; K.C Wong Education Foundation ; CAS ; CAS ; Hubei Provincial Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; K.C Wong Education Foundation ; K.C Wong Education Foundation ; CAS ; CAS ; Hubei Provincial Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; K.C Wong Education Foundation ; K.C Wong Education Foundation ; CAS ; CAS ; Hubei Provincial Natural Science Foundation of China ; Hubei Provincial Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/14202]
专题	中国科学院武汉物理与数学研究所
通讯作者	Zhou, Xin
作者单位	1.Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Coll Chem, Minist Educ, Wuhan 430079, Hubei, Peoples R China 2.Natl Chung Cheng Univ, Dept Chem & Biochem, 168 Univ Rd, Chiayi 621, Taiwan 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Xin,Liu, Maili,Zhang, Aidong,et al. Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging[J]. NANO LETTERS,2019,19(1):441-448.
APA	Zhou, Xin.,Liu, Maili.,Zhang, Aidong.,Hwang, Dennis W..,Xie, Junshuai.,...&Yang, Yuqi.(2019).Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging.NANO LETTERS,19(1),441-448.
MLA	Zhou, Xin,et al."Engineered Paramagnetic Graphene Quantum Dots with Enhanced Relaxivity for Tumor Imaging".NANO LETTERS 19.1(2019):441-448.