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	Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear
	Wang, Xin-Long2; Wu, Ze-Hong1; Di, Lei2; Zhou, Feng-Jiao2; Yan, Yong-Ming1; Cheng, Yong-Xian1
刊名	PHYTOCHEMISTRY
	2019-06-01
卷号	162页码:199-206
关键词	Ganoderma cochlear (Ganodermataceae) Meroterpenoid Calculated ECD Renoprotection
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2019.03.019
通讯作者	Cheng, Yong-Xian(yxcheng@szu.edu.cn)
英文摘要	Twelve previously undescribed phenolic meroterpenoids, cochlearols N-Y, along with two known analogs, ganocochlearins B and C, were isolated from the fruiting bodies of Ganoderma cochlear. Most of these substances were isolated as racemic mixtures. The structures of cochlearols N-Y were assigned based upon spectroscopic data and theoretical calculations. The renoprotective activities of these compounds were evaluated using normal and diseased rat renal interstitial fibroblast cells (NRK-49F). The results show that ganocochlearins S, U, X and Y display potent inhibitory activities against fibronectin overproduction in TGF-beta 1-induced NRK-49F cells.
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
WOS记录号	WOS:000469157200020
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/67389]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Sch Pharmaceut Sci, Sch Med,Hlth Sci Ctr, Shenzhen 518060, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,et al. Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear[J]. PHYTOCHEMISTRY,2019,162:199-206.
APA	Wang, Xin-Long,Wu, Ze-Hong,Di, Lei,Zhou, Feng-Jiao,Yan, Yong-Ming,&Cheng, Yong-Xian.(2019).Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear.PHYTOCHEMISTRY,162,199-206.
MLA	Wang, Xin-Long,et al."Renoprotective phenolic meroterpenoids from the mushroom Ganoderma cochlear".PHYTOCHEMISTRY 162(2019):199-206.

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