Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection

doi:10.1007/s00340-018-6898-9

CORC > 光电技术研究所 > 中国科学院光电技术研究所 > 薄膜光学技术研究室（十一室）

	Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection
	Zhou, Sheng 1,2; Han, Yanling 1; Li, Bincheng 1,3
刊名	APPLIED PHYSICS B-LASERS AND OPTICS
	2018-02-01
卷号	124 期号:2 页码:27
关键词	Absorption spectroscopy Band structure Infrared devices Nitric oxide Quantum cascade lasers
ISSN号	0946-2171
DOI	10.1007/s00340-018-6898-9
文献子类	J
英文摘要	Nitric oxide (NO) in exhaled breath has gained increasing interest in recent years mainly driven by the clinical need to monitor inflammatory status in respiratory disorders, such as asthma and other pulmonary conditions. Mid-infrared cavity ring-down spectroscopy (CRDS) using an external cavity, widely tunable continuous-wave quantum cascade laser operating at 5.3 mu m was employed for NO detection. The detection pressure was reduced in steps to improve the sensitivity, and the optimal pressure was determined to be 15 kPa based on the fitting residual analysis of measured absorption spectra. A detection limit (1 sigma, or one time of standard deviation) of 0.41 ppb was experimentally achieved for NO detection in human breath under the optimized condition in a total of 60 s acquisition time (2 s per data point). Diurnal measurement session was conducted for exhaled NO. The experimental results indicated that mid-infrared CRDS technique has great potential for various applications in health diagnosis.
WOS关键词	NITRIC-OXIDE ; BREATH ; LASER ; AIR ; CHILDREN ; SENSOR ; GAS
语种	英语
WOS记录号	WOS:000424352000005
内容类型	期刊论文
源URL	[http://ir.ioe.ac.cn/handle/181551/9259]
专题	光电技术研究所_薄膜光学技术研究室（十一室）
作者单位	1.Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu; Shuangliu; 610209, China; 2.Graduate University of Chinese Academy of Sciences, Beijing; 100049, China; 3.School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu; 610054, China
推荐引用方式 GB/T 7714	Zhou, Sheng,Han, Yanling,Li, Bincheng. Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection[J]. APPLIED PHYSICS B-LASERS AND OPTICS,2018,124(2):27.
APA	Zhou, Sheng,Han, Yanling,&Li, Bincheng.(2018).Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection.APPLIED PHYSICS B-LASERS AND OPTICS,124(2),27.
MLA	Zhou, Sheng,et al."Pressure optimization of an EC-QCL based cavity ring-down spectroscopy instrument for exhaled NO detection".APPLIED PHYSICS B-LASERS AND OPTICS 124.2(2018):27.