Comparison of retinal microvascular changes in eyes with high-tension glaucoma or normal-tension glaucoma: a quantitative optic coherence tomography angiographic study

doi:10.1007/s00417-018-3930-z

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	Comparison of retinal microvascular changes in eyes with high-tension glaucoma or normal-tension glaucoma: a quantitative optic coherence tomography angiographic study
	Xu, Huan; Zhai, Ruyi; Zong, Yuan; Kong, Xiangmei; Jiang, Chunhui; Sun, Xinghuai; He, Yi; Li, Xiqi
刊名	GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
	2018-06-01
卷号	256 期号:6 页码:1179-1186
关键词	High-tension glaucoma Normal-tension glaucoma Retinal vessel density OCTangiography
ISSN号	0721-832X
DOI	10.1007/s00417-018-3930-z
文献子类	J
英文摘要	Purpose The aim of this study is to determine and compare the changes in the retinal vasculature in eyes with high-tension glaucoma (HTG) or normal-tension glaucoma (NTG).Methods The right eyes of 43 HTG subjects, 33 NTG subjects, and 51 age-and sex-matched normal subjects were included in this cross-sectional study. Signals were projected from the internal limiting membrane to retinal pigment epithelium. The retinal perfused vessel densities in the peripapillary and parafoveal regions were measured automatically with optic coherence tomography angiography and the split-spectrum amplitude-decorrelation angiography algorithm.Results Compared with normal eyes, glaucomatous eyes had a smaller retinal nerve fibre layer (RNFL) thickness, smaller full parafoveal retinal thickness, and lower retinal perfused vessel density (PVD) in the peripapillary and parafoveal regions (all P < 0.01). The visual field, RNFL and retinal thicknesses, and PVD in the parafoveal region in the HTG eyes were similar to those in the NTG eyes. However, the NTG eyes had a significantly lower mean PVD than the HTG eyes in the peripapillary region. When the different sectors of the peripapillary region were studied, the difference was still significant in most sectors (all P < 0.05), except the inferotemporal sector (P = 0.676).Conclusions The retinal perfused vessel density is significantly reduced in HTG and NTG eyes, and more prominently in the peripapillary region in NTG eyes.
语种	英语
WOS记录号	WOS:000432412900017
内容类型	期刊论文
源URL	[http://ir.ioe.ac.cn/handle/181551/9381]
专题	光电技术研究所_自适应光学技术研究室（八室）
推荐引用方式 GB/T 7714	Xu, Huan,Zhai, Ruyi,Zong, Yuan,et al. Comparison of retinal microvascular changes in eyes with high-tension glaucoma or normal-tension glaucoma: a quantitative optic coherence tomography angiographic study[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2018,256(6):1179-1186.
APA	Xu, Huan.,Zhai, Ruyi.,Zong, Yuan.,Kong, Xiangmei.,Jiang, Chunhui.,...&Li, Xiqi.(2018).Comparison of retinal microvascular changes in eyes with high-tension glaucoma or normal-tension glaucoma: a quantitative optic coherence tomography angiographic study.GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,256(6),1179-1186.
MLA	Xu, Huan,et al."Comparison of retinal microvascular changes in eyes with high-tension glaucoma or normal-tension glaucoma: a quantitative optic coherence tomography angiographic study".GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 256.6(2018):1179-1186.