A Toxin-Antitoxin System VapBC15 from Synechocystis sp PCC 6803 Shows Distinct Regulatory Features | |
Fei, Qian1,2; Gao, E-Bin3; Liu, Biao3; Wei, Yao4; Ning, Degang1,4 | |
刊名 | GENES |
2018-04-01 | |
卷号 | 9期号:4页码:16 |
关键词 | cyanobacteria Synechocystis PCC6803 type II toxin-antitoxin system VapBC15 regulatory feature |
ISSN号 | 2073-4425 |
DOI | 10.3390/genes9040173 |
英文摘要 | Type II toxin-antitoxin (TA) systems play important roles in bacterial stress survival by regulating cell growth or death. They are highly abundant in cyanobacteria yet remain poorly characterized. Here, we report the identification and regulation of a putative type II TA system from Synechocystis PCC6803, VapBC15. The VapBC15 system is encoded by the chromosomal operon vapBC15. Exogenous expression of VapC15 dramatically arrested cell growth of Escherichia coli and reduced the numbers of colony-forming units (CFU). The VapC15 toxicity could be neutralized by simultaneous or delayed production of VapB15. Biochemical analysis demonstrated the formation of VapB15-VapC15 complexes by the physical interaction between VapB15 and VapC15. Notably, the VapB15 antitoxin up-regulated the transcription of the vapBC15 operon by directly binding to the promoter region, and the VapC15 toxin abolished the up-regulatory effect by destabilizing the binding. Moreover, VapB15 can be degraded by the proteases Lons and ClpXP2s from Synechocystis PCC6803, thus activating the latent toxicity of VapBC15. These findings suggest that VapBC15 represents a genuine TA system that utilizes a distinct mechanism to regulate toxin activity. |
资助项目 | National Natural Science Foundation of China[31471185] ; National Natural Science Foundation of China[31200019] ; Key Research and Development Project of Jiangsu[BE2015330] ; Agricultural Independent Innovation Project of Jiangsu[CX(17)2027] ; Aquaculture San-xin Project of Jiangsu[D2015-11] |
WOS关键词 | ESCHERICHIA-COLI ; CONDITIONAL COOPERATIVITY ; MESSENGER-RNA ; CELL-DEATH ; GROWTH ; TRANSCRIPTION ; BACTERIA ; MODULES ; TRANSLATION ; PERSISTENCE |
WOS研究方向 | Genetics & Heredity |
语种 | 英语 |
出版者 | MDPI |
WOS记录号 | WOS:000435182200001 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research and Development Project of Jiangsu ; Key Research and Development Project of Jiangsu ; Key Research and Development Project of Jiangsu ; Key Research and Development Project of Jiangsu ; Key Research and Development Project of Jiangsu ; Key Research and Development Project of Jiangsu ; Key Research and Development Project of Jiangsu ; Key Research and Development Project of Jiangsu ; Agricultural Independent Innovation Project of Jiangsu ; Agricultural Independent Innovation Project of Jiangsu ; Agricultural Independent Innovation Project of Jiangsu ; Agricultural Independent Innovation Project of Jiangsu ; Agricultural Independent Innovation Project of Jiangsu ; Agricultural Independent Innovation Project of Jiangsu ; Agricultural Independent Innovation Project of Jiangsu ; Agricultural Independent Innovation Project of Jiangsu ; Aquaculture San-xin Project of Jiangsu ; Aquaculture San-xin Project of Jiangsu ; Aquaculture San-xin Project of Jiangsu ; Aquaculture San-xin Project of Jiangsu ; Aquaculture San-xin Project of Jiangsu ; Aquaculture San-xin Project of Jiangsu ; Aquaculture San-xin Project of Jiangsu ; Aquaculture San-xin Project of Jiangsu ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research and Development Project of Jiangsu ; Key Research and Development Project of Jiangsu ; 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内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/30603] |
专题 | 水生生物研究所_其他_期刊论文 |
通讯作者 | Ning, Degang |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, CAS Key Lab Algal Biol, Wuhan 430072, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 3.Jiangsu Univ, Sch Environm & Safety Engn, Zhenjiang 212013, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, Huaian Res Ctr, Huaian 223005, Peoples R China |
推荐引用方式 GB/T 7714 | Fei, Qian,Gao, E-Bin,Liu, Biao,et al. A Toxin-Antitoxin System VapBC15 from Synechocystis sp PCC 6803 Shows Distinct Regulatory Features[J]. GENES,2018,9(4):16. |
APA | Fei, Qian,Gao, E-Bin,Liu, Biao,Wei, Yao,&Ning, Degang.(2018).A Toxin-Antitoxin System VapBC15 from Synechocystis sp PCC 6803 Shows Distinct Regulatory Features.GENES,9(4),16. |
MLA | Fei, Qian,et al."A Toxin-Antitoxin System VapBC15 from Synechocystis sp PCC 6803 Shows Distinct Regulatory Features".GENES 9.4(2018):16. |
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