Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp (Ctenopharyngodon idella)

doi:10.1016/j.fsi.2018.06.013

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物分子与细胞生物学研究中心 > 期刊论文

	Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp (Ctenopharyngodon idella)
	Huang, Chen 1; Wu, Pei 1,2,3; Jiang, Wei-Dan 1,2,3; Liu, Yang 1,2,3; Zeng, Yun-Yun 1,2,3; Jiang, Jun 1; Kuang, Sheng-Yao 4; Tang, Ling 4; Zhang, Yong-An 5; Zhou, Xiao-Qiu 1,2,3
刊名	FISH & SHELLFISH IMMUNOLOGY
	2018-09-01
卷号	80 期号:1 页码:376-391
关键词	Deoxynivalenol Grass carp (Ctenopharyngodon idella) Intestine Oxidative damage Apoptosis Tight junctions
ISSN号	1050-4648
DOI	10.1016/j.fsi.2018.06.013
英文摘要	Deoxynivalenol (DON) is one of the most common mycotoxin contaminants of animal feed worldwide and brings significant threats to the animal production. However, studies concerning the effect of DON on fish intestine are scarce. This study explored the effects of DON on intestinal physical barrier in juvenile grass carp (Ctenopharyngodon idella). A total of 1440 juvenile grass carp (12.17 +/- 0.01 g) were fed six diets containing graded levels of DON (27, 318, 636, 922, 1243 and 1515 mu g/kg diet) for 60 days. This study for the first time documented that DON caused body malformation in fish, and histopathological lesions, oxidative damage, declining antioxidant capacity, cell apoptosis and destruction of tight junctions in the intestine of fish. The results indicated that compared with control group (27 mu g/kg diet), DON: (1) increased the reactive oxygen species (ROS), malondialdehyde (MDA) and protein carbonyl (PC) content, and up-regulated the mRNA levels of Kelch-like-ECH-associated protein 1 (Keap1: Keap1a but not Keap1b), whereas decreased glutathione (GSH) content and antioxidant enzymes activities, and down-regulated the mRNA levels of antioxidant enzymes (except GSTR in MI) and NF-E2-related factor 2 (Nrf2), as well as the protein levels of Nrf2 in fish intestine. (2) up-regulated cysteinyl aspartic acid-protease (caspase) -3, -7, -8, -9, apoptotic protease activating factor-1 (Apaf-1), Bcl2-associated X protein (Bax), Fas ligand (FasL) and c-Jun N-terminal protein kinase (JNK) mRNA levels, whereas down-regulated B-cell lymphoma-2 (bcl-2) and myeloid cell leukemia-1 (Mcl-1) mRNA levels in fish intestine. (3) down-regulated the mRNA levels of ZO-1, ZO-2b, occludin, claudin-c, -f, -7a, -7b, -11 (except claudin-b and claudin-3c), whereas up-regulated the mRNA levels of claudin-12, -15a (not -15b) and myosin light chain kinase (MLCK) in fish intestine. All above data indicated that DON caused the oxidative damage, apoptosis and the destruction of tight junctions via Nrf2, JNK and MLCK signaling in the intestine of fish, respectively. Finally, based on PWG, FE, PC and MDA, the safe dose of DON for grass carp were all estimated to be 318 mu g/kg diet.
资助项目	National Basic Research Program of China (973 Program)[2014CB138600] ; National Department Public Benefit Research Foundation (Agriculture) of China[201003020] ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Science and Technology Support Program of Sichuan Province of China[2014NZ0003] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2013NC0045] ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2015CC0011] ; modern agricultural industry technology system of Sichuan freshwater fish innovation team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team[2017TD0002] ; Earmarked Found for China Agriculture Research System[CARS-45]
WOS关键词	NF-KAPPA-B ; TIGHT JUNCTION PROTEINS ; TRICHOTHECENE VOMITOXIN DEOXYNIVALENOL ; NONSPECIFIC IMMUNE-RESPONSE ; INDUCED OXIDATIVE DAMAGE ; DISEASE RESISTANCE ; HYDROGEN-PEROXIDE ; AEROMONAS-HYDROPHILA ; EPITHELIAL-CELLS ; ORAL-EXPOSURE
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种	英语
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号	WOS:000440958100040
资助机构	National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; 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内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/30518]
专题	水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
通讯作者	Zhou, Xiao-Qiu; Feng, Lin
作者单位	1.Sichuan Agr Univ, Anim Nutr Inst, Chengdu 611130, Sichuan, Peoples R China 2.Sichuan Agr Univ, Fish Nutr & Safety Prod Univ, Key Lab Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China 3.Sichuan Agr Univ, Key Lab Anim Dis Resistance Nutr China, Minist Educ, Chengdu 611130, Sichuan, Peoples R China 4.Sichuan Acad Anim Sci, Anim Nutr Inst, Chengdu 610066, Sichuan, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Huang, Chen,Wu, Pei,Jiang, Wei-Dan,et al. Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp (Ctenopharyngodon idella)[J]. FISH & SHELLFISH IMMUNOLOGY,2018,80(1):376-391.
APA	Huang, Chen.,Wu, Pei.,Jiang, Wei-Dan.,Liu, Yang.,Zeng, Yun-Yun.,...&Feng, Lin.(2018).Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp (Ctenopharyngodon idella).FISH & SHELLFISH IMMUNOLOGY,80(1),376-391.
MLA	Huang, Chen,et al."Deoxynivalenol decreased the growth performance and impaired intestinal physical barrier in juvenile grass carp (Ctenopharyngodon idella)".FISH & SHELLFISH IMMUNOLOGY 80.1(2018):376-391.