Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp (Ctenopharyngodon idella)

doi:10.1016/j.fsi.2017.12.009

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物分子与细胞生物学研究中心 > 期刊论文

	Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp (Ctenopharyngodon idella)
	Wu, Pei 1,2,3; Tian, Li 1; Zhou, Xiao-Qiu 1,2,3; Jiang, Wei-Dan 1,2,3; Liu, Yang 1,2,3; Jiang, Jun 1,2,3; Xie, Fei 4; Kuang, Sheng-Yao 5; Tang, Ling 5; Tang, Wu-Neng 5
刊名	FISH & SHELLFISH IMMUNOLOGY
	2018-02-01
卷号	73 期号:1 页码:121-132
关键词	Sodium butyrate Intestinal physical barrier Nrf2 JNK Grass carp (Ctenopharyngodon idella)
ISSN号	1050-4648
DOI	10.1016/j.fsi.2017.12.009
英文摘要	This study evaluated the effect of dietary sodium butyrate (SB) supplementation on the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella). The fish were fed one powdery sodium butyrate (PSB) diet (1000.0 mg kg-1 diet) and five graded levels of microencapsulated sodium butyrate (MSB) diets: 0.0 (control), 500.0, 1000.0, 1500.0 and 2000.0 mg kg-1 diet for 60 days. Subsequently, a challenge test was conducted by injection of Aeromonas hydrophila to explore the effect of SB supplementation on intestinal physical barrier function and the potential mechanisms in fish. The results showed that optimal SB supplementation: (1) down-regulated the cysteine-aspartic protease-2 (caspase-2), caspase-3 (rather than PI), caspase-7, caspase-8 (rather than PI), caspase-9, fatty add synthetase ligand (FasL), apoptotic protease activating factor-1 (Apaf-1), B-cell lymphoma 2 associated X protein (Bax) and c-Jun Nterminal protein kinase (JNK) mRNA levels, up-regulated the B-cell lymphoma protein-2 (Bcl-2) (rather than PI), inhibitor of apoptosis proteins (LAP) and myeloid cell leukemia-1 (Mcl-1) mRNA levels in the intestine (P < 0.05), inhibited the intestinal cell apoptosis, maintained the intestine cell structure integrity; (2) increased NF-E2-related factor 2 (Nrf2) mRNA levels and nucleus protein levels, and down-regulated kelch-like-ECH-associated protein (Keapib) (rather than Keapla) mRNA levels in the intestine, up-regulated copper/zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase la (GPx1a), GPx1b, GPx4a, GPx4b, glutathione S-transferases R (GSTR), GSTP1, GSTP2, GSTO1, GSTO2 and glutathione reductase (GR) mRNA levels in the intestine, increased the corresponding antioxidant enzymes activity (P < 0.05), thus enhancing the ability of scavenging free radicals and decreasing the reactive oxygen species (ROS) content, decreasing the lipid and protein peroxidation, as well as alleviating oxidative damage; (3) down-regulated the molecule myosin light chain kinase (MLCK) mRNA levels in the intestine, and up-regulated the occludin, zonula occludens-1 (ZO-1), ZO-2, claudin-b, claudin-c, claudin-f, claudin-3c (rather than PI), claudin-7a, claudin-7b and claudin-11 mRNA levels, down-regulated claudin-12, claudin-15a and claudin-15b mRNA levels (P < 0.05), thus maintaining the structural integrity between cells. This study suggests that SB supplementation could improve fish intestinal physical barrier function. Furthermore, according to the positive effect, MSB was superior to PSB on improving intestinal physical barrier function of fish. Finally, based on protein carbonyl content in the PI, the optimal SB supplementation (MSB as SB source) for young grass carp was estimated to be 338.8 mg kg-1 diet.
资助项目	National Basic Research Program of China (973 Program)[2014CB138600] ; National Department Public Benefit Research Foundation (Agriculture) of China[201003020] ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Science and Technology Support Program of Sichuan Province of China[2014NZ0003] ; Earmarked Fund for China Agriculture Research System[CARS-45] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2012NC0007] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2013NC0045] ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2015CC0011] ; Natural Science Foundation for Young Scientists of Sichuan Province[2014JQ0007]
WOS关键词	NF-KAPPA-B ; MESSENGER-RNA EXPRESSION ; TIGHT JUNCTION STRUCTURE ; MUCOSAL IMMUNE-SYSTEM ; PACIFIC WHITE SHRIMP ; BREAM SPARUS-AURATA ; SALMON SALMO-SALAR ; OXIDATIVE STRESS ; GROWTH-PERFORMANCE ; AEROMONAS-HYDROPHILA
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种	英语
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号	WOS:000424853100015
资助机构	National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture) ; Science and Technology Support Program of Sichuan Province of China ; Science and Technology Support Program of Sichuan Province of China ; 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Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/29925]
专题	水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
通讯作者	Feng, Lin
作者单位	1.Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China 2.Sichuan Agr Univ, Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China 3.Sichuan Agr Univ, Key Lab Anim Dis Resistance Nutr, China Minist Educ, Chengdu 611130, Sichuan, Peoples R China 4.Shanghai Menon Anim Nutr Technol Co Ltd, Shanghai 201807, Peoples R China 5.Sichuan Acad Anim Sci, Inst Anim Nutr, Chengdu 610066, Sichuan, Peoples R China 6.Tongwei Co Ltd, Enterprise Technol Ctr, Chengdu 610041, Sichuan, Peoples R China 7.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China 8.Chengdu Mytech Biotech Co Ltd, Chengdu 610222, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Wu, Pei,Tian, Li,Zhou, Xiao-Qiu,et al. Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp (Ctenopharyngodon idella)[J]. FISH & SHELLFISH IMMUNOLOGY,2018,73(1):121-132.
APA	Wu, Pei.,Tian, Li.,Zhou, Xiao-Qiu.,Jiang, Wei-Dan.,Liu, Yang.,...&Feng, Lin.(2018).Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp (Ctenopharyngodon idella).FISH & SHELLFISH IMMUNOLOGY,73(1),121-132.
MLA	Wu, Pei,et al."Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp (Ctenopharyngodon idella)".FISH & SHELLFISH IMMUNOLOGY 73.1(2018):121-132.