ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis | |
Chen, Geng1,2; Xiong, Lv1,2; Wang, Yumeng1,3; He, Libo1; Huang, Rong1; Liao, Lanjie1; Zhu, Zuoyan1; Wang, Yaping1 | |
刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
2018-10-01 | |
卷号 | 19期号:10页码:18 |
关键词 | grass carp grass carp reovirus integrin endocytosis clathrin apoptosis |
ISSN号 | 1422-0067 |
DOI | 10.3390/ijms19103175 |
英文摘要 | Integrin -1 (ITGB1) is a transmembrane protein belonging to the integrin family and it plays an important role in viral entry. In this study, the itgb1b gene of the rare minnow, Gobiocypris rarus, was cloned and analyzed. To investigate the possible role of itgb1b on grass carp reovirus (GCRV) infection, we generated an ITGB1b-deficient rare minnow (ITGB1b(-/-)) using the CRISPR/Cas9 system. Following stimulation with GCRV, the survival time of the -ITGB1b(-/-) rare minnows was extended in comparison to the wild-type minnows. Moreover, the relative copy number of GCRV and the level of clathrin-mediated endocytosis-associated and apoptosis-related gene expression in the ITGB1b(-/-) rare minnows was significantly lower than that of the wild-type minnows. These results suggested that the absence of itgb1b reduced viral entry efficiency and the expression of apoptosis-related genes. Moreover, the data suggested that itgb1b played an important role in mediating the entry of viruses into the cells via clathrin. Therefore, these findings provide novel insight into the function of itgb1b in the process of GCRV infection. |
资助项目 | National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31702332] |
WOS关键词 | MOUTH-DISEASE VIRUS ; MAMMALIAN REOVIRUS ; CELL ENTRY ; INTEGRIN ; RECEPTOR ; INFECTION ; CORECEPTOR ; TRANSDUCTION ; EXPRESSION ; REQUIRES |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | MDPI |
WOS记录号 | WOS:000448951000330 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/29117] |
专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
通讯作者 | Wang, Yaping |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430074, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 3.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Geng,Xiong, Lv,Wang, Yumeng,et al. ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(10):18. |
APA | Chen, Geng.,Xiong, Lv.,Wang, Yumeng.,He, Libo.,Huang, Rong.,...&Wang, Yaping.(2018).ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(10),18. |
MLA | Chen, Geng,et al."ITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.10(2018):18. |
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