Perfluorobutanesulfonate Exposure Causes Durable and Transgenerational Dysbiosis of Gut Microbiota in Marine Medaka

doi:10.1021/acs.estlett.8b00597

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	Perfluorobutanesulfonate Exposure Causes Durable and Transgenerational Dysbiosis of Gut Microbiota in Marine Medaka
	Chen, Lianguo 1; Lam, James C. W.2,3; Hu, Chenyan 4; Tsui, Mirabelle M. P.2; Wang, Qi 2; Giesy, John P.5,6; Lam, Paul K. S.2
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
	2018-12-01
卷号	5 期号:12 页码:731-738
ISSN号	2328-8930
DOI	10.1021/acs.estlett.8b00597
英文摘要	Environmental pollutants are known as disruptors of gut microbiota. However, it remains unexplored whether the dysbiosis of gut microbiota by pollutants is durable and transgenerational in teleost. Therefore, this study exposed eggs of marine medaka to environmentally realistic concentrations (0, 1.0, 2.9, or 9.5 mu g/L) of perfluorobutanesulfonate (PFBS), a persistent organic pollutant of emerging concern, until sexual maturity. A proportion of F0 adults was dissected after exposure (F0-exposed). Remaining fish were depurated in clean seawater (F0-depurated). F1 offspring were also cultured in clean seawater for a complete life-cycle. Substantial amounts of PFBS were accumulated in F0-exposed intestines, while F1 intestines contained no PFBS. Significant alterations were observed in physiological activities of F0-exposed and F1 medaka. The gut microbial community in F0-exposed, F0-depurated, and F1 medaka were restructured in a concentration-dependent manner by PFBS exposure. Dysbiosis of gut microbiota caused by PFBS exposure was durable in parents and persisted in the offspring. Significant positive correlations were constructed for the genus Cetobacterium with host intestinal epithelial permeability and production of endotoxin lipopolysaccharides. Overall, this study provided the first insight into durable and transgenerational dysbiosis of gut microbiota and intestinal health by PFBS, highlighting the particular susceptibility of gut to xenobiotic stresses.
资助项目	Research Grants Council Theme-Based Research Scheme[T21-602/16-R] ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20160608153654409] ; High Level Foreign Experts program - State Administration of Foreign Experts Affairs[GDT20143200016] ; P.R China ; Einstein Professor Program of the Chinese Academy of Sciences ; Education University of Hong of Kong
WOS关键词	ENVIRONMENTAL-POLLUTANTS ; HOST HEALTH ; PERFLUOROALKYL ; DISRUPTION ; METABOLISM ; RESPONSES ; RECOVERY ; REVEALS ; ACID ; MICE
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000453489400005
资助机构	Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Research Grants Council Theme-Based Research Scheme ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; Shenzhen Basic Research Subject Layout Program from the Science, Technology and Innovation Commission of Shenzhen Municipality ; 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内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/28891]
专题	水生生物研究所_其他_期刊论文
通讯作者	Chen, Lianguo
作者单位	1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 2.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China 3.Educ Univ Hong Kong, Dept Sci & Environm Studies, Tai Po, 10 Lo Ping Rd, Hong Kong, Peoples R China 4.Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430072, Hubei, Peoples R China 5.Univ Saskatchewan, Dept Vet Biomed Sci, 44 Campus Dr, Saskatoon, SK S7N 5B3, Canada 6.Univ Saskatchewan, Toxicol Ctr, 44 Campus Dr, Saskatoon, SK S7N 5B3, Canada
推荐引用方式 GB/T 7714	Chen, Lianguo,Lam, James C. W.,Hu, Chenyan,et al. Perfluorobutanesulfonate Exposure Causes Durable and Transgenerational Dysbiosis of Gut Microbiota in Marine Medaka[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,2018,5(12):731-738.
APA	Chen, Lianguo.,Lam, James C. W..,Hu, Chenyan.,Tsui, Mirabelle M. P..,Wang, Qi.,...&Lam, Paul K. S..(2018).Perfluorobutanesulfonate Exposure Causes Durable and Transgenerational Dysbiosis of Gut Microbiota in Marine Medaka.ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,5(12),731-738.
MLA	Chen, Lianguo,et al."Perfluorobutanesulfonate Exposure Causes Durable and Transgenerational Dysbiosis of Gut Microbiota in Marine Medaka".ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS 5.12(2018):731-738.