Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits

doi:10.1016/j.urology.2018.10.058

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 其他

	Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits
	Hua, Xiaoliang ; Chen, Juan ; Xu, Yujie ; Li, Bing 1
刊名	UROLOGY
	2019-04-01
卷号	126 页码:209-215
ISSN号	0090-4295
DOI	10.1016/j.urology.2018.10.058
通讯作者	Li, Bing(bingli@hust.edu.cn)
英文摘要	OBJECTIVE To investigate the efficacy of a combined dorsal plus ventral double tunica vaginalis graft for urethral reconstruction in a rabbit model through radiology and histopathology. METHODS Thirty adult male New Zealand rabbits were randomly divided into 6 groups as follows (n = 5): normal, stricture, and experimental groups A, B, C, and D. In the stricture and experimental groups, the ventral urethra was incised longitudinally, and the dorsal and ventral urethral mucosa were partially removed. Then, 3 x 20 mm and 5 x 20 mm tunica vaginalis grafts were obtained to repair the dorsal and ventral urethral mucosa defects, respectively, and the spongiosum was closed in the experimental groups. The urethral defects were not repaired in the stricture group. The rabbits in experimental groups A, B, C, and D were sacrificed at 2 weeks, 4 weeks, 12 weeks, and 24 weeks postoperatively, respectively, and the rabbits in the stricture group were sacrificed at 4 weeks postoperatively. The urethra was harvested for histological analysis. Urethrography was performed before sacrifice in the stricture group and experimental groups B and D. RESULTS The retrograde urethrogram showed that all rabbits in experimental groups B and D had a patent urethra. Histological examination showed that the tunica vaginalis graft completely integrated into the urethra at 4 weeks postoperatively and transformed into a urinary pseudostratified epithelium at 12 weeks postoperatively. CONCLUSION Combined dorsal plus ventral double tunica vaginalis graft urethroplasty is a feasible technique for urethral reconstruction in a rabbit model. (C) 2019 Elsevier Inc.
资助项目	National Natural Science Foundation of China (NSFC)[81671216] ; National Natural Science Foundation of China (NSFC)[81371379]
WOS关键词	URETHRAL STRICTURE DISEASE ; TERM-FOLLOW-UP ; BULBAR URETHROPLASTY ; MUCOSA GRAFT ; ONLAY ; OUTCOMES ; HARVEST
WOS研究方向	Urology & Nephrology
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000462587200051
资助机构	National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC)
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/27843]
专题	水生生物研究所_其他
通讯作者	Li, Bing
作者单位	1.Huazhong Univ Sci & Technol, Dept Urol, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China 2.Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Wannan Med Coll, Affiliated Hosp 1, Dept Urol, Wuhu 241001, Peoples R China
推荐引用方式 GB/T 7714	Hua, Xiaoliang,Chen, Juan,Xu, Yujie,et al. Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits[J]. UROLOGY,2019,126:209-215.
APA	Hua, Xiaoliang,Chen, Juan,Xu, Yujie,&Li, Bing.(2019).Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits.UROLOGY,126,209-215.
MLA	Hua, Xiaoliang,et al."Combined Dorsal Plus Ventral Double Tunica Vaginalis Graft Urethroplasty: An Experimental Study in Rabbits".UROLOGY 126(2019):209-215.