Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation

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	Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation
	Cai, Q; Bei, JZ; Wang, SG
刊名	ACTA POLYMERICA SINICA
	2004-10-01
期号	5 页码:719-725
关键词	Biodegradable Dextran L-lactide Brush-like Tissue Engineering
ISSN号	1000-3304
英文摘要	Comb-like biodegradable polylactide-grafted dextran copolymer (Dextran-g-PLA) was synthesized in a bulk lactide polymerization reaction using dextran derivative as macroinitiator and stannous octoate as catalyst. The Dextran-g-PLA copolymers were characterized by H-1-NMR, GPC and intrinsic viscosity measurements, and their molecular architecture was confirmed as PLA segments attached to dextran backbones. Compared to pure PLA, the copolymers showed higher hydrophilicity and faster degradation rate due to the incorporation of hydrophilic glucose units and comb-like structure, which resulted in shortened PLA chain length. This Dextran-g-PLA copolymer was envisioned having good cell affinity and being a good candidate as cell scaffold materials for tissue engineering applications.
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000224710100019
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/81729]
专题	中国科学院化学研究所
通讯作者	Cai, Q
作者单位	Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Cai, Q,Bei, JZ,Wang, SG. Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation[J]. ACTA POLYMERICA SINICA,2004(5):719-725.
APA	Cai, Q,Bei, JZ,&Wang, SG.(2004).Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation.ACTA POLYMERICA SINICA(5),719-725.
MLA	Cai, Q,et al."Study on a comb-like copolymer derived from dextran and L-lactide: Synthesis and degradation".ACTA POLYMERICA SINICA .5(2004):719-725.