Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides

doi:10.1021/j0101832e

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	Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides
	Li, Xin 1,2; Hu, Shenshen 3; Xi, Zhiguo 1,2; Zhang, Long 3; Luo, Sanzhong 3; Cheng, Jin-Pei 1,2
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2010-12-17
卷号	75 期号:24 页码:8697-8700
ISSN号	0022-3263
DOI	10.1021/j0101832e
英文摘要	A highly diastereo- and enantioselective Michael addition reaction with respect to prochiral 3-substituted benzofuran-2(3H)-ones and maleimides by a chiral bifunctional thiourea-tertiary amine catalyst was investigated. The corresponding adducts, containing a quaternary center at the C3-position of the benzofuran-2(3H)-one as well as a vicinal tertiary center, were generally obtained in high yields (up to 99%) with very good diastereo- (up to > 20:1 dr) and enantioselectivities (up to 97% cc).
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000285081100048
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/70551]
专题	中国科学院化学研究所
通讯作者	Li, Xin
作者单位	1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China 2.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Xin,Hu, Shenshen,Xi, Zhiguo,et al. Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides[J]. JOURNAL OF ORGANIC CHEMISTRY,2010,75(24):8697-8700.
APA	Li, Xin,Hu, Shenshen,Xi, Zhiguo,Zhang, Long,Luo, Sanzhong,&Cheng, Jin-Pei.(2010).Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides.JOURNAL OF ORGANIC CHEMISTRY,75(24),8697-8700.
MLA	Li, Xin,et al."Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides".JOURNAL OF ORGANIC CHEMISTRY 75.24(2010):8697-8700.