Aqueous Solution Properties of the Acid-Labile Thermoresponsive Poly(meth)acrylamides with Pendent Cyclic Orthoester Groups

doi:10.1021/ma902227g

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	Aqueous Solution Properties of the Acid-Labile Thermoresponsive Poly(meth)acrylamides with Pendent Cyclic Orthoester Groups
	Du, Fu-Sheng; Huang, Xiao-Nan; Chen, Guang-Tao; Lin, Shrong-Shi; Liang, Dehai; Li, Zi-Chen
刊名	MACROMOLECULES
	2010-03-09
卷号	43 期号:5 页码:2474-2483
ISSN号	0024-9297
DOI	10.1021/ma902227g
英文摘要	A series of poly(meth)acrylamide derivatives with pendent six-member cyclic orthoester groups, i.e., poly(N-(2-alkyloxy-1,3-dioxan-5-yl)methacrylamide)s and poly(N-(2-alkyloxy-1,3-dioxan-5-yl)acrylamide)s, have been synthesized and characterized. The difference between these polymers lies in the type of alkyl substitutes (R(3)), the stereochemical structures of the pendent cyclic orthoester groups (trans vs cis), and the main chain Structures (polymethacrylamide vs polyacrylamide). Aqueous solution properties and pH-dependent hydrolysis behaviors of these polymers were studied by various methods including turbidimetry, fluorescence probe, DSC, (1)H NMR, microscopy, and light scattering. The results show that these polymers except PtNPM can be dissolved in water at low temperature, and all of the water-soluble polymers are thermosensitive with different lower critical solution temperatures (LCSTs) and susceptible to hydrolysis in mildly acidic conditions. Both thermosensitive properties and acid-triggered hydrolysis behaviors of the polymers arc closely related to the polymer structures. In general, polymethacrylamides display higher cloud points (CPS) than polyacrylamides. In addition, the polymers with larger R(3) and trans configuration have a lower CP and greater magnitude of dehydration and exhibit a liquid-solid phase transition, while those with smaller R(3) and cis configuration have a smaller magnitude of dehydration and undergo it liquid-liquid phase separation. In addition, a two-stage transition process is observed for the polymers with R(3) being methyl. (1)H NMR results reveal that the acid-triggered hydrolysis rate of the pendent orthoesters increases, changed from methyl to isopropyl, and the configuration changed from cis to trans. The synergetic effect of R(3) and stereochemical structure of the pendent groups on the hydrolysis products of the polymers were also observed
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000274928400049
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/69053]
专题	中国科学院化学研究所
通讯作者	Li, Zi-Chen
作者单位	Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys, Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Du, Fu-Sheng,Huang, Xiao-Nan,Chen, Guang-Tao,et al. Aqueous Solution Properties of the Acid-Labile Thermoresponsive Poly(meth)acrylamides with Pendent Cyclic Orthoester Groups[J]. MACROMOLECULES,2010,43(5):2474-2483.
APA	Du, Fu-Sheng,Huang, Xiao-Nan,Chen, Guang-Tao,Lin, Shrong-Shi,Liang, Dehai,&Li, Zi-Chen.(2010).Aqueous Solution Properties of the Acid-Labile Thermoresponsive Poly(meth)acrylamides with Pendent Cyclic Orthoester Groups.MACROMOLECULES,43(5),2474-2483.
MLA	Du, Fu-Sheng,et al."Aqueous Solution Properties of the Acid-Labile Thermoresponsive Poly(meth)acrylamides with Pendent Cyclic Orthoester Groups".MACROMOLECULES 43.5(2010):2474-2483.