Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin

doi:10.1002/mabi.200900021

CORC > 化学研究所 > 中国科学院化学研究所

	Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin
	Ren, Lixia 1; He, Lihong 1,2; Sun, Tongchen 1; Dong, Xia 1; Chen, Yongming 1; Huang, Jin 3; Wang, Chun 4
刊名	MACROMOLECULAR BIOSCIENCE
	2009-09-09
卷号	9 期号:9 页码:902-910
关键词	Cyclodextrins Drug Delivery Grafted Copolymers Hydrogels Stimulus Responsive
ISSN号	1616-5187
DOI	10.1002/mabi.200900021
英文摘要	Novel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with a-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000270283800011
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/68577]
专题	中国科学院化学研究所
通讯作者	Chen, Yongming
作者单位	1.Chinese Acad Sci, Inst Chem, Div Polymer Sci & Mat, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN USA 3.Wuhan Univ Technol, Coll Chem Engn, Wuhan 430070, Peoples R China 4.Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA
推荐引用方式 GB/T 7714	Ren, Lixia,He, Lihong,Sun, Tongchen,et al. Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin[J]. MACROMOLECULAR BIOSCIENCE,2009,9(9):902-910.
APA	Ren, Lixia.,He, Lihong.,Sun, Tongchen.,Dong, Xia.,Chen, Yongming.,...&Wang, Chun.(2009).Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin.MACROMOLECULAR BIOSCIENCE,9(9),902-910.
MLA	Ren, Lixia,et al."Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin".MACROMOLECULAR BIOSCIENCE 9.9(2009):902-910.