Acid-Sensitive Polymeric Micelles Based on Thermoresponsive Block Copolymers with Pendent Cyclic Orthoester Groups

doi:10.1021/ma802138r

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	Acid-Sensitive Polymeric Micelles Based on Thermoresponsive Block Copolymers with Pendent Cyclic Orthoester Groups
	Huang, Xiaonan 1; Du, Fusheng 1; Cheng, Jing 1; Dong, Yongquan 1; Liang, Dehai 1; Ji, Shouping 2; Lin, Shrong-Shi 1; Li, Zichen 1
刊名	MACROMOLECULES
	2009-02-10
卷号	42 期号:3 页码:783-790
ISSN号	0024-9297
DOI	10.1021/ma802138r
英文摘要	An orthoester-containing monomer, trans-N-(2-ethoxy-1,3-dioxan-5-yl)acrylamide (tNEA), was synthesized. Atom transfer radical polymerization of tNEA using a poly(ethylene glycol) (PEG) macroinitiator afforded three acid-labile thermoresponsive block copolymers: PEG-b-PtNEA(27), PEG-b-PtNEA(56), and PEG-b-PtNEA(73), These block copolymers are water-soluble at low temperatures (< 13 degrees C). Thermally induced phase transition behaviors, including the critical aggregation temperatures (CATs), of these polymers were investigated by light scattering and (1)H NMR. The results indicated that the longer the PtNEA chain length, the lower the CAT. Upon heating above the CATs, all the three polymers underwent a phase transition and formed polymeric micelles or micelle-like nanoparticles with PEG as the shell and PtNEA block as the core. Both the sizes and morphologies of the micelles were found to be affected by the heating rate and the salt concentration in the buffers. The micelles, formed through a fast heating procedure ill the buffer with a relatively high salt concentration, have a smaller size and a more compacted structure. pH-dependent destabilization of the polymeric micelles prepared from PEG-b-PtNEA(73) was studied by using light scattering and Nile Red fluorescence. The results demonstrated that hydrophobic Nile Red could be loaded in the micelles that were stable at pH 7.4, but destabilized in mildly acidic media. The dissociation of the micelles and the subsequent release of Nile Red were induced by the acid-triggered hydrolysis of the orthoester groups, which was proved by the (1)H NMR spectra.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000263035100030
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/67835]
专题	中国科学院化学研究所
通讯作者	Du, Fusheng
作者单位	1.Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Beijing Inst Transfus Med, Dept Mol Biol, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Huang, Xiaonan,Du, Fusheng,Cheng, Jing,et al. Acid-Sensitive Polymeric Micelles Based on Thermoresponsive Block Copolymers with Pendent Cyclic Orthoester Groups[J]. MACROMOLECULES,2009,42(3):783-790.
APA	Huang, Xiaonan.,Du, Fusheng.,Cheng, Jing.,Dong, Yongquan.,Liang, Dehai.,...&Li, Zichen.(2009).Acid-Sensitive Polymeric Micelles Based on Thermoresponsive Block Copolymers with Pendent Cyclic Orthoester Groups.MACROMOLECULES,42(3),783-790.
MLA	Huang, Xiaonan,et al."Acid-Sensitive Polymeric Micelles Based on Thermoresponsive Block Copolymers with Pendent Cyclic Orthoester Groups".MACROMOLECULES 42.3(2009):783-790.