Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility

doi:10.1016/j.colsurfb.2009.02.014

CORC > 化学研究所 > 中国科学院化学研究所

	Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility
	Huangfu, Peng-bo 1; Gong, Ming 1; Zhang, Cunfu 2; Yang, Shan 1; Zhao, Jiang 2; Gong, Yong-kuan 1
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2009-07-01
卷号	71 期号:2 页码:268-274
关键词	Phosphorylcholine Chitosan Hemocompatibility Surface Modification Contact Angle Xps
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2009.02.014
英文摘要	A novel strategy has been developed to improve the hemocompatibility of chitosan surface by cell outer membrane mimetic structure able to reduce protein adsorption and cell adhesion. Phosphorylcholine dichloride was synthesized and grafted onto a glutaraldehyde-cross-linked chitosan (CS-GA) film surface to prepare phosphorylcholine-coated CS-GA film (CS-GA-PC) through a heterogeneous reaction process. The spectroscopic and contact angle characterization show that a cell outer membrane mimetic structure was formed on the cross-linked chitosan surface, and the significantly improved hemocompatibility of the modified surface was shown by a suppression of 94% on platelet adhesion, a suppression of 60-70% for bovine plasma fibrinogen and bovine serum albumin adsorptions. These results demonstrated that this cell outer membrane mimetic surface modification with phosphorylcholine dichloride is a promising strategy to improve the hemocompatibility of chitosan. (C) 2009 Elsevier BY. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000266897900016
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/67579]
专题	中国科学院化学研究所
通讯作者	Gong, Yong-kuan
作者单位	1.NW Univ Xian, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Coll Chem & Mat Sci, Xian 710069, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Huangfu, Peng-bo,Gong, Ming,Zhang, Cunfu,et al. Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2009,71(2):268-274.
APA	Huangfu, Peng-bo,Gong, Ming,Zhang, Cunfu,Yang, Shan,Zhao, Jiang,&Gong, Yong-kuan.(2009).Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility.COLLOIDS AND SURFACES B-BIOINTERFACES,71(2),268-274.
MLA	Huangfu, Peng-bo,et al."Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility".COLLOIDS AND SURFACES B-BIOINTERFACES 71.2(2009):268-274.