Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(L-lactide) composites

doi:10.1016/j.actbio.2008.02.013

CORC > 化学研究所 > 中国科学院化学研究所

	Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(L-lactide) composites
	Liu, Aixue 1,2; Hong, Zhongkui 1,2; Zhuang, Xiuli 1; Chen, Xuesi 1,2; Cui, Yang 3; Liu, Yi 3; Jing, Xiabin 1,2
刊名	ACTA BIOMATERIALIA
	2008-07-01
卷号	4 期号:4 页码:1005-1015
关键词	Polylactide Bioactive Glass Nanoparticles Composites Mechanical Properties
ISSN号	1742-7061
DOI	10.1016/j.actbio.2008.02.013
英文摘要	Novel bioactive glass (13G) nanoparticles/poly(L-lactide) (PLLA) composites were prepared as promising bone-repairing materials. The BG nanoparticles (Si:P:Ca = 29:13:58 weight ratio) of about 40 run diameter were prepared via the sol-gel method. In order to improve the phase compatibility between the polymer and the inorganic phase, PLLA (M-n = 9700 Da) was linked to the surface of the BG particles by diisocyanate. The grafting ratio of PLLA was in the vicinity of 20 wt.%. The grafting modification could improve the tensile strength, tensile modulus and impact energy of the composites by increasing the phase compatibility. When the filler loading reached around 4 wt.%, the tensile strength of the composite increased from 56.7 to 69.2 MPa for the pure PLLA, and the impact strength energy increased from 15.8 to 18.0 kJ m(-2). The morphology of the tensile fracture surface of the composite showed surface-grafted bioactive glass particles (g-BG) to be dispersed homogeneously in the PLLA matrix. An in vitro bioactivity test showed that, compared to pure PLLA scaffold, the BG/PLLA nanocomposite demonstrated a greater capability to induce the formation of an apatite layer on the scaffold surface. The results of marrow stromal cell culture revealed that the composites containing either BG or g-BG particles have much better biocompatibility compared to pure PLLA material. (c) 2008 Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000257266300025
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/63877]
专题	中国科学院化学研究所
通讯作者	Chen, Xuesi
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Jilin Univ, Hosp 1, Dept Spine Surg, Changchun 130021, Peoples R China
推荐引用方式 GB/T 7714	Liu, Aixue,Hong, Zhongkui,Zhuang, Xiuli,et al. Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(L-lactide) composites[J]. ACTA BIOMATERIALIA,2008,4(4):1005-1015.
APA	Liu, Aixue.,Hong, Zhongkui.,Zhuang, Xiuli.,Chen, Xuesi.,Cui, Yang.,...&Jing, Xiabin.(2008).Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(L-lactide) composites.ACTA BIOMATERIALIA,4(4),1005-1015.
MLA	Liu, Aixue,et al."Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(L-lactide) composites".ACTA BIOMATERIALIA 4.4(2008):1005-1015.