Modulation of fibrillogenesis of amyloid beta(1-40) peptide with cationic gemini surfactant

doi:10.1021/jp075271b

CORC > 化学研究所 > 中国科学院化学研究所

	Modulation of fibrillogenesis of amyloid beta(1-40) peptide with cationic gemini surfactant
	Cao, Meiwen; Han, Yuchun; Wang, Jinben; Wang, Yilin
刊名	JOURNAL OF PHYSICAL CHEMISTRY B
	2007-11-29
卷号	111 期号:47 页码:13436-13443
ISSN号	1520-6106
DOI	10.1021/jp075271b
英文摘要	Modulation of the fibrillogenesis of amyloid peptide A beta(1-40) with the cationic gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (C12C6C12Br2) has been studied. Both UV-vis and AFM results show that C12C6C12Br2 monomers can promote the fibrillogenesis of A beta(1-40) while its micelles inhibit this process. The electrostatic/hydrophobic force balance plays important roles in determining the A beta(1-40) aggregation style and the secondary structures. When the surfactant positive charges are close to the A beta(1-40) negative charges in number, the hydrophobic interaction is highly enhanced in the system. Both the nucleation rate and the lateral association between fibrils are greatly promoted. However, when the surfactant positive charges are in excess of the A beta(1-40) negative charges, the electrostatic interaction is strengthened. In this case, the lateral association is inhibited and the (alpha-helix to beta-sheet transition in the secondary structure is prevented. Simultaneously, another assembly pathway is induced to give the amorphous aggregates. Moreover, the size and surface roughness of the A beta(1-40) aggregates also vary upon increasing C12C6C12Br2 concentration.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000251140900012
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/61259]
专题	中国科学院化学研究所
通讯作者	Wang, Yilin
作者单位	Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Cao, Meiwen,Han, Yuchun,Wang, Jinben,et al. Modulation of fibrillogenesis of amyloid beta(1-40) peptide with cationic gemini surfactant[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2007,111(47):13436-13443.
APA	Cao, Meiwen,Han, Yuchun,Wang, Jinben,&Wang, Yilin.(2007).Modulation of fibrillogenesis of amyloid beta(1-40) peptide with cationic gemini surfactant.JOURNAL OF PHYSICAL CHEMISTRY B,111(47),13436-13443.
MLA	Cao, Meiwen,et al."Modulation of fibrillogenesis of amyloid beta(1-40) peptide with cationic gemini surfactant".JOURNAL OF PHYSICAL CHEMISTRY B 111.47(2007):13436-13443.