Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice

doi:10.1016/j.bcp.2005.12.001

CORC > 化学研究所 > 中国科学院化学研究所

	Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice
	Wang, JX ; Chen, CY ; Li, B ; Yu, HW ; Zhao, YL ; Sun, J ; Li, YF ; Xing, GM ; Yuan, H ; Tang, J
刊名	BIOCHEMICAL PHARMACOLOGY
	2006-03-14
卷号	71 期号:6 页码:872-881
关键词	[Gd@c-82(Oh)(22)](n) Nanoparticles Oxidative Stress Antioxidant Biodistribution In Vivo
ISSN号	0006-2952
DOI	10.1016/j.bcp.2005.12.001
英文摘要	Oxidative stress is considered to be one of the important mechanisms involved in carcinogenesis. In our previous study, gadolinium endohedral metallofullerenol ([Gd@C-82(OH)(22)](n) nanoparticles) have shown high inhibitory activity on hepatoma cell (H22) growth in mice. To explore the antioxidative functions of nanoparticles, we investigated the biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles, the changes of blood coagulation profiles, the metabolism of reactive oxygen species (ROS) in the tumor-bearing mice as well as the possible relationships between nanoparticles treatment and ROS production in this paper. The activities of hepatic superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and catalase (CAT) as well as the levels of reduced glutathione (GSH), protein-bound thiols and malondialdehyde (MDA) were compared between the tumor-bearing mice and normal mice. Transplanted tumors were grown in mice by subcutaneous injection of murine hepatoma cells in the mice. The comparison of the above parameters between nanoparticles and cyclophosphamide (CTX) therapy were also investigated. [Gd@C-82(OH)(22)](n). administration can efficiently restore the damaged liver and kidney of the tumor-bearing mice. All the activities of enzymes and other parameters related to oxidative stress were reduced after [Gd@C-82(OH)(22)](n) treatment and tended closely to the normal levels. The results suggest that [Gd@C-82(OH)(22)](n) nanoparticle treatment could regulate ROS production in vivo. (c) 2005 Elsevier Inc. All rights reserved.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000235723100018
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/59583]
专题	中国科学院化学研究所
通讯作者	Chen, CY
作者单位	1.Chinese Acad Sci, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, JX,Chen, CY,Li, B,et al. Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice[J]. BIOCHEMICAL PHARMACOLOGY,2006,71(6):872-881.
APA	Wang, JX.,Chen, CY.,Li, B.,Yu, HW.,Zhao, YL.,...&Wan, LJ.(2006).Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice.BIOCHEMICAL PHARMACOLOGY,71(6),872-881.
MLA	Wang, JX,et al."Antioxidative function and biodistribution of [Gd@C-82(OH)(22)](n) nanoparticles in tumor-bearing mice".BIOCHEMICAL PHARMACOLOGY 71.6(2006):872-881.