Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia

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	Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia
	He Li ; Zhou Gang ; He Yuling ; Xie Luokun ; Xiong Jie ; Lei Hao ; Wei Li ; Hu Chunsong ; Liu Junyan ; Jiang Mingshen
刊名	JOURNAL OF IMMUNOLOGY
	2006-09-15
卷号	177 期号:6 页码:3644-3656
ISSN号	0022-1767
英文摘要	What mechanism that determines microglia accomplishing destructive or constructive role in CNS remains nebulous. We report here that intracranial priming and rechallenging with Toxoplasma gondii in mice elicit neurotoxic CCR9(+)Irg1(+) (immunoresponsive gene 1) microglia, which render resistance to apoptosis and produce a high level of TNF-alpha; priming and rechallenging with lymphocytic choriomeningitis virus elicit neurosupportive CXCR3(+)Irg1(-) microglia, which are sensitive to apoptosis and produce a high level of IL-10 and TGF-beta. Administration of CCR9 and/or Irg1 small interfering RNA alters the frequency and functional profiles of neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(+) microglia in vivo. Moreover, by using a series of different neurotropic pathogens, including intracellular parasites, chronic virus, bacteria, toxic substances, and CNS injury to intracranially prime and subsequent rechallenge mice, the bi-directional elicitation of microglia has been confirmed as neurotoxic CCR9(+)Irg1(+) and neurosupportive CXCR3(+)Irg1(+) cells in these mouse models. These data suggest that there exist two different types of microglia, providing with a novel insight into microglial involvement in neurodegenerative and neuroinflammatory pathogenesis such as Alzheimer's disease and AIDS dementia.
语种	英语
出版者	AMER ASSOC IMMUNOLOGISTS
WOS记录号	WOS:000240475300017
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/59363]
专题	中国科学院化学研究所
通讯作者	Tan Jinquan
作者单位	1.Wuhan Univ, Sch Med, Dept Immunol, Wuhan 430071, Peoples R China 2.Wuhan Univ, Sch Med, Dept Parasitol, Inst Allegy & Immunerealted Dis, Wuhan 430071, Peoples R China 3.Wuhan Univ, Sch Med, Neurosci Lab, Wuhan 430071, Peoples R China 4.Wuhan Univ, Sch Med, Lab Allergy & Clin Immunol, Med Res Ctr, Wuhan 430071, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Mol Biol & Neurosci, Inst Biochem & Cell Biol, Shanghai, Peoples R China 6.Chinese Acad Sci, Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 7.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface Sci & Chem Thermodynam, Beijing 100080, Peoples R China 8.Anhui Med Univ, Coll Basic Med Sci, Dept Immunol, Hefei, Peoples R China 9.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430074, Peoples R China 10.Fourth Mil Med Univ, Dept Immunol, Xian 710032, Peoples R China
推荐引用方式 GB/T 7714	He Li,Zhou Gang,He Yuling,et al. Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia[J]. JOURNAL OF IMMUNOLOGY,2006,177(6):3644-3656.
APA	He Li.,Zhou Gang.,He Yuling.,Xie Luokun.,Xiong Jie.,...&Tan Jinquan.(2006).Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia.JOURNAL OF IMMUNOLOGY,177(6),3644-3656.
MLA	He Li,et al."Different neurotropic pathogens elicit neurotoxic CCR9-or neurosupportive CXCR3-expressing microglia".JOURNAL OF IMMUNOLOGY 177.6(2006):3644-3656.