Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility

doi:10.1016/j.biomaterials.2005.04.018

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	Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility
	Hong, ZK; Zhang, PB; He, CL; Qiu, XY; Liu, AX; Chen, L; Chen, XS; Jing, XB
刊名	BIOMATERIALS
	2005-11-01
卷号	26 期号:32 页码:6296-6304
关键词	Polylactide Hydroxyapatite Composite Mechanical Properties Biocompatibility Cell Culture
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2005.04.018
英文摘要	In order to improve the bonding between hydroxyapatite (HAP) particles and poly(t-lactide) (PLLA), and hence to increase mechanical properties of the PLLA/HAP composite as potential bone substitute material. the HAP nano-particles were surface-grafted with PLLA and further blended with PLLA. The structure and properties of the composites were subsequently investigated by the mechanical property testing, the differential scanning calorimeter measurements (DSC), the scanning electron microscopy (SEM), the polarized optical microscopy (POM), and the cell culture. The PLLA molecules grafted oil (lie HAP surfaces, as inter-tying molecules, played an important role in improving the adhesive strength between the particles and the polymer matrix. At a low content (similar to 4 wt%) of surface grafted-HAP (g-HAP), the PLLA/g-HAP nano-composites exhibited higher bending strength and impact energy than the pristine PLLA, and at a higher g-HAP content (e.g., 20wt%), the modulus was remarkably increased, It implied that PLLA could be strengthened as well as toughened by g-HAP nano-particles. The results of biocompatibility test showed that the g-HAP existing in the PLLA composite facilitated both adhesion and proliferation of chondrocytes on the PLLA, g-HAP composite film, (c) 2005 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000231189600005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/57419]
专题	中国科学院化学研究所
通讯作者	Chen, XS
作者单位	Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Hong, ZK,Zhang, PB,He, CL,et al. Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility[J]. BIOMATERIALS,2005,26(32):6296-6304.
APA	Hong, ZK.,Zhang, PB.,He, CL.,Qiu, XY.,Liu, AX.,...&Jing, XB.(2005).Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility.BIOMATERIALS,26(32),6296-6304.
MLA	Hong, ZK,et al."Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility".BIOMATERIALS 26.32(2005):6296-6304.