Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization

doi:10.1016/j.biomaterials.2004.11.002

CORC > 化学研究所 > 中国科学院化学研究所

	Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization
	Tian, HY; Deng, C; Lin, H; Sun, JR; Deng, MX; Chen, XS; Jing, XB
刊名	BIOMATERIALS
	2005-07-01
卷号	26 期号:20 页码:4209-4217
关键词	Polyethylenimine Biodegradable Hyperbranched Amphiphilic Copolymer Micelle Complex Micelle Drug Delivery
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2004.11.002
英文摘要	A novel amphiphilic biodegradable cationic hyperbranched poly(ethylene glycol)-polyethylenimine-poly(gamma-benzyl L-glutamate) (PEG-PEI-PBLG) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with PEG-PEI as a macroinitiator. PEG-PEI was firstly prepared by coupling of PEG and PEI using hexamethylene diisocyanate (HMDI). The structural properties of PEG-PEI-PBLG copolymers were confirmed by H-1 NMR and GPC. The copolymers were found to be self-assembled in water with critical micelle concentration (CMC) in the range of 0.00368-0.0125 g/l and high hydrophobic micelle core. The micelle size and CMC obviously depended on the hydrophobic block content in the copolymer and the ionic state of the PEI block. The CMC decreased with the increase in the PBLG block content. The decrease of micelle size and the increase of CMC simultaneously occurred with the protonated degree of PEI block by addition of HCl solution. ESEM and Gel retardation assay showed that the cationic micelles had ability to encapsulate plasmid DNA. The copolymer has potential medical applications in drug and gene delivery. (C) 2004 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000227369000001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/56783]
专题	中国科学院化学研究所
通讯作者	Chen, XS
作者单位	Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Tian, HY,Deng, C,Lin, H,et al. Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization[J]. BIOMATERIALS,2005,26(20):4209-4217.
APA	Tian, HY.,Deng, C.,Lin, H.,Sun, JR.,Deng, MX.,...&Jing, XB.(2005).Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization.BIOMATERIALS,26(20),4209-4217.
MLA	Tian, HY,et al."Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization".BIOMATERIALS 26.20(2005):4209-4217.