Degradation in vitro and cell affinity of poly (L-lactide-co-beta-malic acid)

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	Degradation in vitro and cell affinity of poly (L-lactide-co-beta-malic acid)
	He, B; Wan, YQ; Bei, JZ; Wang, SG
刊名	ACTA POLYMERICA SINICA
	2004-10-01
期号	5 页码:693-699
关键词	Poly( L-lactide-co-beta-malic Acid) Biodegradation Cell Attachment
ISSN号	1000-3304
英文摘要	The degradation behavior of a novel functionalized biodegradable poly(L-lactide-co-beta-malic acid) in pH 7.4 PBS was studied, and mice 3T3 fibroblasts were cultivated on copolymer films to evaluate the cell affinity of copolymers. The variation of weight loss, surface morphology, composition and molecular weight of copolymers were investigated. The results showed that the degradation of poly( L-lactide-co-beta-malic acid) was bulk degradation, the malic acid could accelerate the degradation rate, the ester bonds near PMA segments hydrolyzed prior to the ester bonds in PLLA. The cell attachment rate of 3T3 fibroblasts on the surface of PLLA, PLMA96/4, PLMA92/8 and PLMA87/13 was 43% 71% 80% and 43%, respectively when cultivated for 5 h, the morphology of 3T3 fibroblast was better on the surface of PLMA96/4 and PLMA92/8 than that on the surface of PLLA and PLMA87/13 when cultivated for 24 h.
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000224710100014
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/55273]
专题	中国科学院化学研究所
通讯作者	He, B
作者单位	Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	He, B,Wan, YQ,Bei, JZ,et al. Degradation in vitro and cell affinity of poly (L-lactide-co-beta-malic acid)[J]. ACTA POLYMERICA SINICA,2004(5):693-699.
APA	He, B,Wan, YQ,Bei, JZ,&Wang, SG.(2004).Degradation in vitro and cell affinity of poly (L-lactide-co-beta-malic acid).ACTA POLYMERICA SINICA(5),693-699.
MLA	He, B,et al."Degradation in vitro and cell affinity of poly (L-lactide-co-beta-malic acid)".ACTA POLYMERICA SINICA .5(2004):693-699.