Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles

doi:10.2217/nnm.14.111

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	Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles
	Xu, Yingying 1; Tang, Huan 1; Wang, Haifang 2; Liu, Yuanfang 1,2
刊名	NANOMEDICINE
	2015
卷号	10 期号:3 页码:419-431
关键词	Gastrointestinal Tract Oral Tolerance Ovalbumin Silver Nanoparticles
ISSN号	1743-5889
DOI	10.2217/nnm.14.111
英文摘要	Aim: The authors investigated the effect of silver nanoparticles (Ag NPs) on oral tolerance to dietary antigen ovalbumin (OVA) in mice. Materials & methods: Ag NPs were orally administered for 7 days before feeding of OVA and the immunological responses were assayed. Results: Polyvinyl pyrrolidone-coated Ag NPs (Ag NPs-PVP) were found to block the induction of oral tolerance to OVA. The physicochemical properties of the three kinds of Ag NPs were assessed and silver ions were found to inhibit the induction of oral tolerance, which might be the dominating factor in the blockade of oral tolerance by Ag NPs-PVP. Conclusion: Ag NPs with certain physicochemical properties can block oral tolerance to dietary antigen that may induce food allergy in humans.
语种	英语
出版者	FUTURE MEDICINE LTD
WOS记录号	WOS:000350246600008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/53471]
专题	中国科学院化学研究所
通讯作者	Wang, Haifang
作者单位	1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yingying,Tang, Huan,Wang, Haifang,et al. Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles[J]. NANOMEDICINE,2015,10(3):419-431.
APA	Xu, Yingying,Tang, Huan,Wang, Haifang,&Liu, Yuanfang.(2015).Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles.NANOMEDICINE,10(3),419-431.
MLA	Xu, Yingying,et al."Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles".NANOMEDICINE 10.3(2015):419-431.