Bacterial chemoreceptors and chemoeffectors

doi:10.1007/s00018-014-1770-5

CORC > 化学研究所 > 中国科学院化学研究所

	Bacterial chemoreceptors and chemoeffectors
	Bi, Shuangyu 1,4; Lai, Luhua 1,2,3
刊名	CELLULAR AND MOLECULAR LIFE SCIENCES
	2015-02-01
卷号	72 期号:4 页码:691-708
关键词	Chemotactic Response Receptor Ligand Molecular Mechanism Receptor Design
ISSN号	1420-682X
DOI	10.1007/s00018-014-1770-5
英文摘要	Bacteria use chemotaxis signaling pathways to sense environmental changes. Escherichia coli chemotaxis system represents an ideal model that illustrates fundamental principles of biological signaling processes. Chemoreceptors are crucial signaling proteins that mediate taxis toward a wide range of chemoeffectors. Recently, in deep study of the biochemical and structural features of chemoreceptors, the organization of higher-order clusters in native cells, and the signal transduction mechanisms related to the on-off signal output provides us with general insights to understand how chemotaxis performs high sensitivity, precise adaptation, signal amplification, and wide dynamic range. Along with the increasing knowledge, bacterial chemoreceptors can be engineered to sense novel chemoeffectors, which has extensive applications in therapeutics and industry. Here we mainly review recent advances in the E. coli chemotaxis system involving structure and organization of chemoreceptors, discovery, design, and characterization of chemoeffectors, and signal recognition and transduction mechanisms. Possible strategies for changing the specificity of bacterial chemoreceptors to sense novel chemoeffectors are also discussed.
语种	英语
出版者	SPRINGER BASEL AG
WOS记录号	WOS:000348918500004
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/53423]
专题	中国科学院化学研究所
通讯作者	Lai, Luhua
作者单位	1.Peking Univ, Ctr Quantitat Biol, Beijing 100871, Peoples R China 2.Peking Univ, BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China 3.Peking Univ, Peking Tsinghua Ctr Life Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 4.Max Planck Inst Terr Microbiol, D-35043 Marburg, Germany
推荐引用方式 GB/T 7714	Bi, Shuangyu,Lai, Luhua. Bacterial chemoreceptors and chemoeffectors[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2015,72(4):691-708.
APA	Bi, Shuangyu,&Lai, Luhua.(2015).Bacterial chemoreceptors and chemoeffectors.CELLULAR AND MOLECULAR LIFE SCIENCES,72(4),691-708.
MLA	Bi, Shuangyu,et al."Bacterial chemoreceptors and chemoeffectors".CELLULAR AND MOLECULAR LIFE SCIENCES 72.4(2015):691-708.