Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro

doi:10.1002/adfm.201403119

CORC > 化学研究所 > 中国科学院化学研究所

	Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro
	Zhang, He 1; Fei, Jinbo 1; Yan, Xuehai 2; Wang, Anhe 3; Li, Junbai 1
刊名	ADVANCED FUNCTIONAL MATERIALS
	2015-02-25
卷号	25 期号:8 页码:1193-1204
ISSN号	1616-301X
DOI	10.1002/adfm.201403119
英文摘要	Small aldehyde molecule are demonstrated to induce cationic diphenylalanine to assemble into monodisperse enzyme-responsive nanocarriers with high biocompatibility and excellent biodegradability. The formation of Schiff base covalent bond and accompanying pi-pi interaction of aromatic rings are found to be the mainly driving forces for the assembly of the nanocarriers. Interestingly, the nanocarriers show autofluorescence due to the n-pi* transitions of C = N bonds, which lends them visually traceable property in living cells. Importantly, the nanocarriers can be taken in by cells and biodegraded in the cells. In addition, doxorubicin is easily loaded into the nanocarriers with high encapsulation amount, and its release can be triggered by tyrisin under physiological conditions. Noticeably, even at a very low drug concentration, the doxorubicin-loaded nanocarriers still exhibit a much higher killing capacity of HeLa cells in vitro, compared to the equivalent-dose free doxorubicin, indicating they have a great potential biomedical application.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000349817200003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/53389]
专题	中国科学院化学研究所
通讯作者	Zhang, He
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, He,Fei, Jinbo,Yan, Xuehai,et al. Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(8):1193-1204.
APA	Zhang, He,Fei, Jinbo,Yan, Xuehai,Wang, Anhe,&Li, Junbai.(2015).Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro.ADVANCED FUNCTIONAL MATERIALS,25(8),1193-1204.
MLA	Zhang, He,et al."Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro".ADVANCED FUNCTIONAL MATERIALS 25.8(2015):1193-1204.