Tetrathiafulvalene Terminal-Decorated PAMAM Dendrimers for Triggered Release Synergistically Stimulated by Redox and CB[7]

doi:10.1021/la404349w

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	Tetrathiafulvalene Terminal-Decorated PAMAM Dendrimers for Triggered Release Synergistically Stimulated by Redox and CB[7]
	Zhang, Xiaohui 1; Zeng, Yi 1; Yu, Tianjun 1; Chen, Jinping 1; Yang, Guoqiang 2; Li, Yi 1
刊名	LANGMUIR
	2014-01-28
卷号	30 期号:3 页码:718-726
ISSN号	0743-7463
DOI	10.1021/la404349w
英文摘要	A series of polyamidoamine (PAMAM) dendrimers with tetrathiafulvalene (TTF) at the periphery (Gn-PAMAM-TTF), generation 0-2, were synthesized. These functionalized dendrimers exist as nanospheres with diameters around 80-100 nm in aqueous phase, which can encapsulate hydrophobic molecules. The terminal TTF groups can go through a reversible redox process upon addition of the oxidizing and reducing agents. Each terminal TTF+center dot group of the oxidized Gn-PAMAM-TTF assembled with cucurbit[7]uril (CB[7]) forming a 1:1 inclusion complex with association constants of (3.14 +/- 0.36) x 10(5), (1.29 +/- 0.12) x 10(6), and (1.79 +/- 0.24) x 10(6) M-1 for generation 0-2, respectively, even at the aggregate state. The formation of the inclusion complex loosened the structure of the nanospheres and initiated the release of cargo, and the release mechanism was validated by dynamic light scattering (DLS), cryo-transmission electron microscopy (TEM), and electron paramagnetic resonance (EPR) experiments. This study provides a potential strategy for the development of drug delivery systems synergistically triggered by redox and supramolecular assembly.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000330543700006
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/53217]
专题	中国科学院化学研究所
通讯作者	Zeng, Yi
作者单位	1.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Photochem, BNLMS, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiaohui,Zeng, Yi,Yu, Tianjun,et al. Tetrathiafulvalene Terminal-Decorated PAMAM Dendrimers for Triggered Release Synergistically Stimulated by Redox and CB[7][J]. LANGMUIR,2014,30(3):718-726.
APA	Zhang, Xiaohui,Zeng, Yi,Yu, Tianjun,Chen, Jinping,Yang, Guoqiang,&Li, Yi.(2014).Tetrathiafulvalene Terminal-Decorated PAMAM Dendrimers for Triggered Release Synergistically Stimulated by Redox and CB[7].LANGMUIR,30(3),718-726.
MLA	Zhang, Xiaohui,et al."Tetrathiafulvalene Terminal-Decorated PAMAM Dendrimers for Triggered Release Synergistically Stimulated by Redox and CB[7]".LANGMUIR 30.3(2014):718-726.