Synergistic Antitumor Effects of Doxorubicin-Loaded Carboxymethyl Cellulose Nanoparticle in Combination with Endostar for Effective Treatment of Non-Small-Cell Lung Cancer

doi:10.1002/adhm.201400108

CORC > 化学研究所 > 中国科学院化学研究所

	Synergistic Antitumor Effects of Doxorubicin-Loaded Carboxymethyl Cellulose Nanoparticle in Combination with Endostar for Effective Treatment of Non-Small-Cell Lung Cancer
	Li, Mingqiang 1,2; Tang, Zhaohui 1; Lin, Jian 1,2; Zhang, Yu 1,2; Lv, Shixian 1,2; Song, Wantong 1; Huang, Yubin 3; Chen, Xuesi 1
刊名	ADVANCED HEALTHCARE MATERIALS
	2014-11-01
卷号	3 期号:11 页码:1877-1888
ISSN号	2192-2640
DOI	10.1002/adhm.201400108
英文摘要	The multi-modal combination therapy is proved powerful and successful to enhance the antitumor efficacy in clinics as compared with single therapy modes. In this study, the potential of combining chemotherapy with antiangiogenic therapy for the treatment of non-small-cell lung cancer is explored. Towards this aim, OEGylated carboxymethyl cellulose-(2-(2-(2-methoxyethoxy)ethoxy)methyl)oxirane (CMC-ME2MO) is prepared by treating CMC with ME2MO in the alkaline aqueous solution, and used to efficiently carry doxorubicin (DOX) with high drug-loading content (16.64%) and encapsulation efficiency (99.78%). As compared to free DOX, the resulting nanoparticles show not only the favorable stability in vitro but also the prolonged blood circulation, improved safety and tolerability, optimized biodistribution, reduced systemic toxicity, and enhanced antitumor efficacy in vivo, indicates a potential utility in cancer chemotherapy. Furthermore, the combination of the DOX-loaded polysaccharide nanoparticles and antiangiogenic drug endostar provides synergistic effects of chemotherapy and antiangiogenic therapy, which shows the highest efficiency in tumor suppression. The combination approach of the DOX-containing nanomedicine and endostar for efficient treatment of non-small-cell lung cancer is first proposed to demonstrate the synergistic therapeutic effect. This synergistic combination proves to be a promising therapeutic regimen in cancer therapy and holds great potential for clinical application.
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000344857000022
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/53001]
专题	中国科学院化学研究所
通讯作者	Chen, Xuesi
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Li, Mingqiang,Tang, Zhaohui,Lin, Jian,et al. Synergistic Antitumor Effects of Doxorubicin-Loaded Carboxymethyl Cellulose Nanoparticle in Combination with Endostar for Effective Treatment of Non-Small-Cell Lung Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2014,3(11):1877-1888.
APA	Li, Mingqiang.,Tang, Zhaohui.,Lin, Jian.,Zhang, Yu.,Lv, Shixian.,...&Chen, Xuesi.(2014).Synergistic Antitumor Effects of Doxorubicin-Loaded Carboxymethyl Cellulose Nanoparticle in Combination with Endostar for Effective Treatment of Non-Small-Cell Lung Cancer.ADVANCED HEALTHCARE MATERIALS,3(11),1877-1888.
MLA	Li, Mingqiang,et al."Synergistic Antitumor Effects of Doxorubicin-Loaded Carboxymethyl Cellulose Nanoparticle in Combination with Endostar for Effective Treatment of Non-Small-Cell Lung Cancer".ADVANCED HEALTHCARE MATERIALS 3.11(2014):1877-1888.