Novel hydroxyl-containing reduction-responsive pseudo-poly(aminoacid) via click polymerization as an efficient drug carrier

doi:10.1039/c4py00227j

CORC > 化学研究所 > 中国科学院化学研究所

	Novel hydroxyl-containing reduction-responsive pseudo-poly(aminoacid) via click polymerization as an efficient drug carrier
	Wu, Yanjuan 1,2; Kuang, Huihui 1,2; Xie, Zhigang 1; Chen, Xuesi 1; Jing, Xiabin 1; Huang, Yubin 1
刊名	POLYMER CHEMISTRY
	2014
卷号	5 期号:15 页码:4488-4498
ISSN号	1759-9954
DOI	10.1039/c4py00227j
英文摘要	A novel biodegradable pseudo-poly(aminoacid) copolymer (mPEG-HRSCP-mPEG) was produced via a mechanism of step polymerization through Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) (click polymerization) using dialkyned-cystine and diazide monomers. The disulfide and hydroxyl groups were repeatedly arranged in the polymer backbone. The introduced hydroxyl groups could not only adjust the hydrophilicity of the amphiphilic polymer, but also improve the DOX loading efficiency and solubility. Compared with the unmodified one, the polymer containing hydroxyl groups has increased hydrophilicity with a larger critical aggregation concentration (CAC) value, lower water contact angle, higher drug loading content and drug loading efficiency. The pH and reduction sensitivities of this drug delivery system (DDS) were investigated using Dynamic Light Scattering (DLS) to monitor the changes of average diameters. DOX was loaded as a model drug and in vitro release experiments demonstrated that DOX release was accelerated by an addition of 10 mM glutathione (GSH) or under acidic conditions rather than under physiological conditions. Our study on in vitro anticancer efficiency showed that DOX-loaded nanoparticles had a higher cytotoxicity towards GSH pretreated HeLa cells. These newly designed copolymer nanoparticles can be used as novel and impactful pH and reduction dual-responsive nanocarriers for intelligent DOX delivery.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000339044000011
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/52617]
专题	中国科学院化学研究所
通讯作者	Huang, Yubin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yanjuan,Kuang, Huihui,Xie, Zhigang,et al. Novel hydroxyl-containing reduction-responsive pseudo-poly(aminoacid) via click polymerization as an efficient drug carrier[J]. POLYMER CHEMISTRY,2014,5(15):4488-4498.
APA	Wu, Yanjuan,Kuang, Huihui,Xie, Zhigang,Chen, Xuesi,Jing, Xiabin,&Huang, Yubin.(2014).Novel hydroxyl-containing reduction-responsive pseudo-poly(aminoacid) via click polymerization as an efficient drug carrier.POLYMER CHEMISTRY,5(15),4488-4498.
MLA	Wu, Yanjuan,et al."Novel hydroxyl-containing reduction-responsive pseudo-poly(aminoacid) via click polymerization as an efficient drug carrier".POLYMER CHEMISTRY 5.15(2014):4488-4498.