Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds

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	Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds
	Feng, Lianshun 1,2,3,4; Tan, Yanhong 3; Wei, Zengquan 1,2; Liu, Mingliang 1,2; Guo, Huiyuan 1,2
刊名	ASIAN JOURNAL OF CHEMISTRY
	2014-07-01
卷号	26 期号:13 页码:3805-3807
关键词	Naphthyridone Derivatives Antibacterial Activity 8-alkoxyimino-1 6-dizaspiro[3.4]Octane Scaffolds
ISSN号	0970-7077
英文摘要	We report herein in vitro antibacterial activity of a series of novel naphthyridone derivatives containing 8-alkoxyimino-1,6-dizaspiro[ 3.4] octane scaffolds, the position isomers of the side chain at the C-7 position of zabofloxacin. Our results revealed that the target compounds were generally less active than the reference against the tested Gram-positive and Gram-negative strains with few exceptions, but compounds 1-5 and 7 showed good activity against MSSA and P. aeruginosa (MICs: 0.25-1 mu g/mL). Especially, compounds 3 and 7 (MICs: 0.25 mu g/mL) were found to be 4 times more potent than or comparable to levofloxacin against P. aeruginosa, the important conditioned pathogen on hospital infection. Simple structure-activity relationship was also discussed in this paper.
语种	英语
出版者	ASIAN JOURNAL OF CHEMISTRY
WOS记录号	WOS:000343763700010
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51347]
专题	中国科学院化学研究所
通讯作者	Liu, Mingliang
作者单位	1.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Peking Univ, Beijing Natl Lab Mol Sci, Dept Biol Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 4.Hybio Pharmaceut Co Ltd, Shenzhen 518057, Peoples R China
推荐引用方式 GB/T 7714	Feng, Lianshun,Tan, Yanhong,Wei, Zengquan,et al. Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds[J]. ASIAN JOURNAL OF CHEMISTRY,2014,26(13):3805-3807.
APA	Feng, Lianshun,Tan, Yanhong,Wei, Zengquan,Liu, Mingliang,&Guo, Huiyuan.(2014).Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds.ASIAN JOURNAL OF CHEMISTRY,26(13),3805-3807.
MLA	Feng, Lianshun,et al."Antibacterial Activity of Naphthyridone Derivatives Containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane Scaffolds".ASIAN JOURNAL OF CHEMISTRY 26.13(2014):3805-3807.