Efficient synthesis of highly enantiopure beta-lactam derivatives from biocatalytic transformations of amides and nitriles

doi:10.1016/j.tet.2014.05.018

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	Efficient synthesis of highly enantiopure beta-lactam derivatives from biocatalytic transformations of amides and nitriles
	Ao, Yu-Fei 1; Leng, Dong-Hui 1; Wang, De-Xian 1; Zhao, Liang 2; Wang, Mei-Xiang 2
刊名	TETRAHEDRON
	2014-07-22
卷号	70 期号:29 页码:4309-4316
关键词	Rhodococcus Erythropolis Aj270 Nitrile Hydratase Amidase Kinetic Resolution 4-carboxymethyl-beta-lactam
ISSN号	0040-4020
DOI	10.1016/j.tet.2014.05.018
英文摘要	Catalyzed by Rhodococcus erythropolis AJ270, a nitrite hydratase and amidase containing microbial strain, under mild conditions, kinetic resolution of racemic amides provides an efficient and scalable route to highly enantioenriched R-4-carboxymethyl-beta-lactams and S-4-carbamoylmethyl-beta-lactams despite the substrates contain a stereogenic center that is beta-positioned to amide functionality. Synthetic potential of the method was demonstrated by the constructions of novel beta-lactam-fused heterocyclic compounds through convenient and practical chemical transformations. (C) 2014 Elsevier Ltd. All rights reserved.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000337868400002
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/50247]
专题	中国科学院化学研究所
通讯作者	Wang, Mei-Xiang
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Ao, Yu-Fei,Leng, Dong-Hui,Wang, De-Xian,et al. Efficient synthesis of highly enantiopure beta-lactam derivatives from biocatalytic transformations of amides and nitriles[J]. TETRAHEDRON,2014,70(29):4309-4316.
APA	Ao, Yu-Fei,Leng, Dong-Hui,Wang, De-Xian,Zhao, Liang,&Wang, Mei-Xiang.(2014).Efficient synthesis of highly enantiopure beta-lactam derivatives from biocatalytic transformations of amides and nitriles.TETRAHEDRON,70(29),4309-4316.
MLA	Ao, Yu-Fei,et al."Efficient synthesis of highly enantiopure beta-lactam derivatives from biocatalytic transformations of amides and nitriles".TETRAHEDRON 70.29(2014):4309-4316.