Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers

doi:10.1016/j.carbpol.2014.04.017

CORC > 化学研究所 > 中国科学院化学研究所

	Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers
	Li, Zhuang 1,2; Kang, Hongliang 1; Che, Ning 1,2; Liu, Zhijing 1,2; Li, Pingping 1,2; Li, Weiwei 1; Zhang, Chao 1,2; Cao, Chun 1,2; Liu, Ruigang 1; Huang, Yong 3
刊名	CARBOHYDRATE POLYMERS
	2014-10-13
卷号	111 页码:18-24
关键词	Core-sheath Nanofibers Electrospinning Cellulose Acetate Liposomes Naproxen Sustained Drug Release
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2014.04.017
英文摘要	Naproxen (NAP) loaded nanofibers of different structures have been successfully prepared by electrospinning. The structures of the nanofibers are NAP and cellulose acetate (CA) mixed nanofibers (NF-1), nanofibers with NAP/CA mixed core and CA sheath (NF-2), and NAP loaded liposomes and sodium hyaluronate (HA-Na) mixed core with CA sheath (NF-3). The structure and morphology of the nanofibers were characterized and the drug release behaviors were investigated. It was found that NAP can disperse in the HA-Na or CA matrix in molecular level without formation of NAP crystals and dimers. The drug release behaviors of NF-1 and NF-2 show a non-Fickian diffusion mechanism, while the NF-3 shows a specific drug release behavior with a burst release within 8 h followed by a sustained drug release for 12 days. The particular two-stage drug release behavior of NF-3 nanofibers offers the materials promising applications as wound dressing materials. (C) 2014 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000340302100003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/49945]
专题	中国科学院化学研究所
通讯作者	Liu, Ruigang
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, Natl Res Ctr Engn Plast, Being 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Zhuang,Kang, Hongliang,Che, Ning,et al. Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers[J]. CARBOHYDRATE POLYMERS,2014,111:18-24.
APA	Li, Zhuang.,Kang, Hongliang.,Che, Ning.,Liu, Zhijing.,Li, Pingping.,...&Huang, Yong.(2014).Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers.CARBOHYDRATE POLYMERS,111,18-24.
MLA	Li, Zhuang,et al."Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers".CARBOHYDRATE POLYMERS 111(2014):18-24.