Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats

doi:10.1016/j.biomaterials.2012.02.062

CORC > 化学研究所 > 中国科学院化学研究所

	Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats
	Liu, Daxing 1,2; Liu, Shi 1,2; Jing, Xiabin 1; Li, Xiaoyuan 1; Li, Wenliang 1,2; Huang, Yubin 1
刊名	BIOMATERIALS
	2012-06-01
卷号	33 期号:17 页码:4362-4369
关键词	Dichloroacetate Electrospun Mats Metabolism Target Atp Depletion Necrosis
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2012.02.062
英文摘要	It is still a great challenge to apply therapeutic concentration of anti-cancer drugs to the tumor site with low system toxicity. An in situ administration strategy was applied to reverse the aerobic glycolysis of tumor in vivo for the first time. Controlled release of therapeutic concentration of dichloroacetate (DCA) from polylactide (PLA) electrospun mats covering the solid tumor locally was designed to suppress the cervical carcinoma in vivo. A dramatic decrease in the volume and weight of tumors was observed for 19 days in tumor-bearing mice, and a totally 96% of the tumor suppression degree was obtained even the initial tumor volume was around 200 mm(3). Half of the mice recovered in less than 3 weeks. Necrosis was examined rather than apoptosis on the tumor cells as the main process of cell death induced by the DCA-loaded electrospun mats. A proposed necroptosis mechanism was presented to explain the signal pathways that were induced by the metabolic remodeling of DCA. It provided support for this strategy that target the bio-energy metabolism of the cervical carcinoma locally is a quick and effective pathway to cure the advanced-carcinoma of cervical. (C) 2012 Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000303181500013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/49411]
专题	中国科学院化学研究所
通讯作者	Huang, Yubin
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Daxing,Liu, Shi,Jing, Xiabin,et al. Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats[J]. BIOMATERIALS,2012,33(17):4362-4369.
APA	Liu, Daxing,Liu, Shi,Jing, Xiabin,Li, Xiaoyuan,Li, Wenliang,&Huang, Yubin.(2012).Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats.BIOMATERIALS,33(17),4362-4369.
MLA	Liu, Daxing,et al."Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats".BIOMATERIALS 33.17(2012):4362-4369.