Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives

doi:10.1016/j.talanta.2011.12.005

CORC > 化学研究所 > 中国科学院化学研究所

	Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives
	Jin, Yue; Chen, Cheng; Meng, Lingchen; Chen, Jitao; Li, Meixian; Zhu, Zhiwei
刊名	TALANTA
	2012-01-30
卷号	89 页码:149-154
关键词	Achiral Ionic Liquid Beta-cyclodextrin Enantioseparation Beta-blocker
ISSN号	0039-9140
DOI	10.1016/j.talanta.2011.12.005
英文摘要	Successful simultaneous enantioseparation and sensitive determination of three beta-blockers (PIN, OX and PRO), have been achieved by capillary electrophoresis using an achiral ionic liquid, [GTMA]Cl, as a modifier to cooperate with dual CDs containing DM-beta-CD and TM-beta-CD. The influence of aIL was investigated in details, including various aILs, the concentration of aIL and molar ratio of aIL to CD. The ratio of DM-beta-CD to TM-beta-CD in dual CDs was also discussed. DM-beta-CD and TM-beta-CD favor the enantioseparations of PIN/OX and PRO, respectively. Meanwhile, the presence of [GTMA]Cl was found to play a key role in enantioseparations, and it widened the scope of application of DM-beta-CD and TM-beta-CD. Furthermore, FESI as an effective on-line sample enrichment technique was developed to improve the detection sensitivity. Under the optimum conditions, the detection limits of the three pairs of enantiomers range from 0.10 to 0.65 nM, which are much lower than those in the conventional methods. Eventually, the proposed method was successfully applied to the analysis of spiked urine sample with good recoveries. (C) 2011 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000301278000022
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/48537]
专题	中国科学院化学研究所
通讯作者	Zhu, Zhiwei
作者单位	Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Jin, Yue,Chen, Cheng,Meng, Lingchen,et al. Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives[J]. TALANTA,2012,89:149-154.
APA	Jin, Yue,Chen, Cheng,Meng, Lingchen,Chen, Jitao,Li, Meixian,&Zhu, Zhiwei.(2012).Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives.TALANTA,89,149-154.
MLA	Jin, Yue,et al."Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives".TALANTA 89(2012):149-154.