Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers

doi:10.1021/nn301735u

CORC > 化学研究所 > 中国科学院化学研究所

	Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers
	Duan, Li 2; Yan, Xuehai 3; Wang, Anhe 1; Jia, Yi 1; Li, Junbai 1
刊名	ACS NANO
	2012-08-01
卷号	6 期号:8 页码:6897-6904
关键词	Hemoglobin Spheres Porous Caco3 Lbl Assembly High Loading Artificial Oxygen Carriers
ISSN号	1936-0851
DOI	10.1021/nn301735u
英文摘要	Seeking safe and effective artificial blood substitutes based on hemoglobin (Hb) as oxygen carriers is an important topic. A significant challenge is to enhance the loading content of Hb in a well-defined structure. Here we report a facile and controllable avenue to fabricate Hb spheres with a high loading content by templating decomposable porous CaCO3 particles in collaboration with covalent layer-by-layer assembly technique. The surface of the Hb spheres was further chemically modified by biocompatible polyethylene glycol to protect and stabilize the system. Multiple characterization techniques were employed to reveal the loading and density of Hb in an individual CaCO3 particle. The results demonstrate that the strategy developed In this work is effective and flexible for construction of the highly loaded Hb spheres. More importantly, such Hb spheres retain their carrying-releasing oxygen function. It may thus have great potential to develop Hb spheres with highly loaded content as realistic artificial blood substitutes in the future.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000307988900043
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/47213]
专题	中国科学院化学研究所
通讯作者	Li, Junbai
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, BNLMS, Beijing 100190, Peoples R China 2.NW Inst Nucl Technol, Xian 710024, Shaanxi, Peoples R China 3.Max Planck Inst Colloids & Interfaces, D-14476 Golm, Germany
推荐引用方式 GB/T 7714	Duan, Li,Yan, Xuehai,Wang, Anhe,et al. Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers[J]. ACS NANO,2012,6(8):6897-6904.
APA	Duan, Li,Yan, Xuehai,Wang, Anhe,Jia, Yi,&Li, Junbai.(2012).Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers.ACS NANO,6(8),6897-6904.
MLA	Duan, Li,et al."Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers".ACS NANO 6.8(2012):6897-6904.