RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin

doi:10.1016/j.biomaterials.2018.02.028

CORC > 化学研究所 > 中国科学院化学研究所

	RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin
	Li, Xue 1,2; Zhen, Mingming 1,2; Deng, Ruijun 1,2; Yu, Tong 1,2; Li, Jie 1,2; Zhang, Ying 1,2; Zou, Toujun 1; Zhou, Yue 1,2; Lu, Zhigao 1,2; Guan, Mirong 1,2
刊名	BIOMATERIALS
	2018-05-01
卷号	163 页码:142-153
关键词	Antitumor Agents Gadofullerenes Radiofrequency Tumor Vascular-disruption Ve-cadherin
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2018.02.028
英文摘要	The tumor vasculature with unique characteristics offers an attractive target for anti-cancer therapy. Herein, we put forward a novel antitumor therapeutic mechanism based on the gadofullerene nano crystals (GFNCs), the agent we have previously shown to efficiently disrupt tumor vasculature by size expansion with assistance of radiofrequency (RF). However, the tumor vascular disrupting mechanism of RF-assisted GFNCs treatment was not further studied. In the present work, a rapid tumor blood flow shutdown has been observed by the vascular perfusion imaging in vivo and vascular damages were evident 6 h after the RF-assisted GFNCs treatment. Importantly, a significant down-expression of tumor vascular endothelial cadherin (VE-cadherin) treated by RF-assisted GFNCs was further investigated, which caused vascular collapse, blood flow shut-down and subsequent tumor hemorrhagic necrosis. These findings set forth a systematic mechanism on the superior anti-tumor efficiency by RF-assisted GFNCs treatment. (C) 2018 The Authors. Published by Elsevier Ltd.
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000428606700013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45985]
专题	中国科学院化学研究所
通讯作者	Zhen, Mingming; Wang, Chunru
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Key Lab Mol Nanostruct &, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Xue,Zhen, Mingming,Deng, Ruijun,et al. RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin[J]. BIOMATERIALS,2018,163:142-153.
APA	Li, Xue.,Zhen, Mingming.,Deng, Ruijun.,Yu, Tong.,Li, Jie.,...&Wang, Chunru.(2018).RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin.BIOMATERIALS,163,142-153.
MLA	Li, Xue,et al."RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin".BIOMATERIALS 163(2018):142-153.