An aptamer-Fe3+ modified nanoparticle for lactate oxidation and tumor photodynamic therapy

doi:10.1016/j.colsurfb.2018.01.045

CORC > 化学研究所 > 中国科学院化学研究所

	An aptamer-Fe3+ modified nanoparticle for lactate oxidation and tumor photodynamic therapy
	Yang, Huan 1; Lu, Wen-Long 1; Huang, Tao 2; Chen, Qiu-Yun 1; Gao, Jing 2; Zhao, Yao 3
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2018-04-01
卷号	164 页码:192-200
关键词	Aptamer Nanoreactor Phototherapy Lactate Cancer
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2018.01.045
英文摘要	To develop a cancer targeting lactate attenuator in vivo for cancer phototherapy and inhibition of HIF-1, we report an aptamer modified photo-responsive nanoparticle (labeled as Mn-D@BPFe-A) for lactate oxidation and cancer phototherapy. Mn-D@BPFe-A was constructed by the assembly of functional complex with BSA, followed by surface metal coordination and the recognition of Fe3+ with GAG containing sequence. Upon irradiation, Mn-D@BPFe-A NPs can oxidize water with the generation of center dot OH, which convert lactate into pyruvate both in vitro and in vivo. Obviously, the Mn-D@BPFe-A exhibits a significant tumor ablation owing to the light driven oxidation of lactic acid and dysfunction of mitochondria. Importantly, it can decrease both the level of lactate in cancer tissues and the expression of HIF-1 alpha and Glut-1 in HepG-2 cells. These results demonstrated that oxidation of lactate with dysfunction of mitochondria by nucleic acid-Fe3+ modified nanoparticle is an effective strategy for the development of non-oxygen dependent photodynamic effect agents. (C) 2018 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000429762100022
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45921]
专题	中国科学院化学研究所
通讯作者	Chen, Qiu-Yun
作者单位	1.Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Peoples R China 2.Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yang, Huan,Lu, Wen-Long,Huang, Tao,et al. An aptamer-Fe3+ modified nanoparticle for lactate oxidation and tumor photodynamic therapy[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018,164:192-200.
APA	Yang, Huan,Lu, Wen-Long,Huang, Tao,Chen, Qiu-Yun,Gao, Jing,&Zhao, Yao.(2018).An aptamer-Fe3+ modified nanoparticle for lactate oxidation and tumor photodynamic therapy.COLLOIDS AND SURFACES B-BIOINTERFACES,164,192-200.
MLA	Yang, Huan,et al."An aptamer-Fe3+ modified nanoparticle for lactate oxidation and tumor photodynamic therapy".COLLOIDS AND SURFACES B-BIOINTERFACES 164(2018):192-200.